Therapeutic correction of hemophilia A using 2D endothelial cells and multicellular 3D organoids derived from CRISPR/Cas9-engineered patient iPSCs

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作者
Son, Jeong Sang [1 ]
Park, Chul-Yong [2 ]
Lee, Gyunggyu [1 ]
Park, Ji Young [1 ]
Kim, Hyo Jin [1 ]
Kim, Gyeongmin [1 ]
Chi, Kyun Yoo [1 ]
Woo, Dong-Hun [3 ]
Han, Choongseong [3 ]
Kim, Sang Kyum [4 ]
Park, Han-Jin [5 ]
Kim, Dong-Wook [2 ]
Kim, Jong-Hoon [1 ]
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[1] Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul,02841, Korea, Republic of
[2] Department of Physiology, Yonsei University College of Medicine, Seoul,03722, Korea, Republic of
[3] Department of Stem Cell Biology, NEXEL Co., Ltd., Seoul,07802, Korea, Republic of
[4] College of Pharmacy, Chungnam National University, Daejeon,34134, Korea, Republic of
[5] Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon,34114, Korea, Republic of
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