Two tandem multicomponent reactions for the synthesis of sequence-defined polymers

被引：0
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作者：
Lu Yang [1 ,2 ]
Ze Zhang [1 ,2 ]
Bofei Cheng [1 ,2 ]
Yezi You [1 ,2 ]
Decheng Wu [3 ,4 ,5 ]
Chunyan Hong [1 ,2 ]
机构：
[1] Key Laboratory of Soft Matter Chemistry, Chinese Academy of Sciences
[2] Department of Polymer Science and Engineering,University of Science and Technology of China
[3] Beijing National Laboratory for Molecular Sciences
[4] State Key Laboratory of Polymer Physics & Chemistry
[5] Institute of Chemistry,Chinese Academy of
来源：
Science China(Chemistry) | 2015年 / 58卷 / 11期
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摘要：
Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new molecule containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high molecular diversity and complexity.
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页码：1734 / 1740
页数：7
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