Two tandem multicomponent reactions for the synthesis of sequence-defined polymers

被引：0

作者：

Lu Yang ^{[1
,2
]}

Ze Zhang ^{[1
,2
]}

Bofei Cheng ^{[1
,2
]}

Yezi You ^{[1
,2
]}

Decheng Wu ^{[3
,4
,5
]}

Chunyan Hong ^{[1
,2
]}

机构：

[1] Key Laboratory of Soft Matter Chemistry, Chinese Academy of Sciences

[2] Department of Polymer Science and Engineering,University of Science and Technology of China

[3] Beijing National Laboratory for Molecular Sciences

[4] State Key Laboratory of Polymer Physics & Chemistry

[5] Institute of Chemistry,Chinese Academy of Sciences

来源：

Science China(Chemistry). | 2015年 / 58卷 / 11期

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new molecule containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high molecular diversity and complexity.

引用

页数：7

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