The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome

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作者：
Guohong Li
机构：
[1] NationalLaboratoryofBio-macromolecules,CASCenterforExcellenceinBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences
来源：
Science China(Life Sciences). | 2020年 / 63卷 / 06期
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摘要：
<正>The genetic information, stored in the linear sequences of DNA, encodes all of the genes that a living organism uses to produce proteins and RNAs essential for various cellular functions. In eukaryotes, however, genomic DNA is hierarchically and efficiently packaged into multiple-level chromatin structures within the nucleus, including the nucleosome, 30 nm fibers, chromatin loops, topology asso-
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