The 4D nucleome project

被引：407

作者：

Dekker, Job ^{[1
]}

Belmont, Andrew S. ^{[2
]}

Guttman, Mitchell ^{[3
]}

Leshyk, Victor O. ^{[4
]}

Lis, John T. ^{[5
]}

Lomvardas, Stavros ^{[6
]}

Mirny, Leonid A. ^{[7
,8
]}

O'Shea, Clodagh C. ^{[9
]}

Park, Peter J. ^{[10
]}

Ren, Bing ^{[11
]}

Politz, Joan C. Ritland ^{[12
]}

Shendure, Jay ^{[13
]}

Zhong, Sheng ^{[4
]}

van den Berg, Aafke

Heckert, Alec Basil

Bertero, Alessandro

Bortnick, Alex

Kukalev, Alexander

Moore, Amanda

Pombo, Ana

Hansen, Anders Sejr

Chiariello, Andrea Maria

Sali, Andrej

Belmont, Andrew

Stephens, Andrew

Nand, Ankita

Valton, Anne-Laure

Goloborodko, Anton

He, Arthur

van Steensel, Bas

Webb, Ben

Roscoe, Benjamin

Li, Bin

Ren, Bing ^{[11
]}

Chait, Brian

Blau, C. Anthony

Annunziatella, Carlo

Ware, Carol

Wei, Chia Lin

Leemans, Christ

Disteche, Christine

Jarjour, Christine

Thieme, Christoph

Murry, Chuck

Barcia, Claudia Trevilla

Trapnell, Cole

Murre, Cornelis

Peric-Hupkes, Daan

Simon, Dan

Bartlett, Daniel

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Syst Biol,Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

[2] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA

[3] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[4] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[5] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[6] Columbia Univ, Dept Biochem & Mol Biophys, Mortimer B Zuckerman Mind Brain & Behav Inst, 630 W 168th St, New York, NY 10027 USA

[7] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[8] MIT, Dept Phys, Cambridge, MA 02139 USA

[9] Salk Inst Biol Studies, Mol & Cell Biol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[10] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA

[11] Univ Calif San Diego, Inst Genom Med, Dept Cellular & Mol Med, Ludwig Inst Canc Res,Moores Canc Ctr, La Jolla, CA 92093 USA

[12] Fred Hutchinson Canc Res Ctr, Basic Sci, 1100 Fairview Ave North, Seattle, WA 98109 USA

[13] Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98109 USA

来源：

NATURE | 2017年 / 549卷 / 7671期

关键词：

HI-C REVEALS; HUMAN GENOME; CHROMOSOME CONFORMATION; IN-VIVO; LOCALIZATION MICROSCOPY; SPATIAL-ORGANIZATION; ELECTRON-MICROSCOPY; CHROMATIN DOMAINS; GENE-EXPRESSION; HIGH-RESOLUTION;

D O I：

10.1038/nature23884

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

引用

页码：219 / 226

页数：8

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