Acute exposure to mercury drives changes in gene expression in Drosophila melanogaster

被引：0
|
作者：
Sanderson, Brian J. [1 ]
Sims-West, Dylan J. [1 ,2 ]
Macdonald, Stuart J. [1 ]
机构：
[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA
[2] Syracuse Univ, Ctr Reprod Evolut, Dept Biol, Syracuse, NY 13244 USA
来源：
BMC RESEARCH NOTES | 2024年 / 17卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Drosophila melanogaster; RNA-seq; Mercury;
D O I：
10.1186/s13104-024-06945-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objective We quantified the effect of acute exposure to a high dosage of inorganic mercury on gene expression in Drosophila melanogaster using RNA-sequencing of whole adult females. Results We found 119 genes with higher gene expression following treatment (including all 5 Drosophila metallothionine genes and a number of heat shock protein genes), and 31 with lower expression (several of which are involved in egg formation). Our results highlight biological processes and genetic pathways impacted by exposure to this toxic metal, and provide motivation for future studies to understand the genetic basis of response to mercury.
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页数：5
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