Synthesis of α-hydroxyketones via palladium-catalyzed arylation of arylglyoxals

被引：0
|
作者：
Li, Si-Yu [1 ]
Ai, Zhao-Pin [1 ]
Guo, Qi-Xiang [1 ]
Wen, Wei [1 ]
机构：
[1] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China
来源：
TETRAHEDRON | 2024年 / 166卷
关键词：
alpha-hydroxyketones; Palladium catalysis; Arylation; Arylglyoxals; FRIEDEL-CRAFTS REACTION; ARYL BORONIC ACIDS; ONE-POT SYNTHESIS; ARYLBORONIC ACIDS; ENANTIOSELECTIVE SYNTHESIS; BENZYL ALCOHOLS; KETONES; HYDROXYLATION; 1,2-ADDITION; DIKETONES;
D O I：
10.1016/j.tet.2024.134214
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed arylation reaction of arylglyoxals with arylboronic acids has been achieved. The reaction produces various acyclic alpha-hydroxyketones in high yields under mild conditions. Of merits mention, the rigorous exclusion of air and moisture is not required in these transformations, offering a straightforward and practical approach for the synthesis of alpha-hydroxyketones.
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页数：7
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