Multi-scale signaling and tumor evolution in high-grade gliomas

被引：7

作者：

Liu, Jingxian ^{[1
,2
]}

Cao, Song ^{[1
,2
]}

Imbach, Kathleen J. ^{[3
,4
]}

Gritsenko, Marina A. ^{[5
]}

Lih, Tung-Shing M. ^{[6
]}

Kyle, Jennifer E. ^{[5
]}

Yaron-Barir, Tomer M. ^{[7
,8
,9
]}

Binder, Zev A. ^{[10
]}

Li, Yize ^{[1
,2
]}

Strunilin, Ilya ^{[1
,2
]}

Wang, Yi-Ting ^{[5
]}

Tsai, Chia-Feng ^{[5
]}

Ma, Weiping ^{[11
]}

Chen, Lijun ^{[6
]}

Clark, Natalie M. ^{[12
]}

Shinkle, Andrew ^{[1
,2
]}

Deen, Nataly Naser Al ^{[1
,2
]}

Caravan, Wagma ^{[1
,2
]}

Houston, Andrew ^{[1
,2
]}

Simin, Faria Anjum ^{[1
,2
]}

Wyczalkowski, Matthew A. ^{[1
,2
]}

Wang, Liang-Bo ^{[1
,2
]}

Storrs, Erik ^{[1
,2
]}

Chen, Siqi ^{[1
,2
]}

Illindala, Ritvik ^{[1
,13
,14
]}

Li, Yuping D. ^{[1
,13
,14
]}

Jayasinghe, Reyka G. ^{[1
,2
]}

Rykunov, Dmitry ^{[11
]}

Cottingham, Sandra L. ^{[15
]}

Chu, Rosalie K. ^{[16
]}

Weitz, Karl K. ^{[5
]}

Moore, Ronald J. ^{[5
]}

Sagendorf, Tyler ^{[5
]}

Petyuk, Vladislav A. ^{[5
]}

Nestor, Michael ^{[5
]}

Bramer, Lisa M. ^{[5
]}

Stratton, Kelly G. ^{[5
]}

Schepmoes, Athena A. ^{[5
]}

Couvillion, Sneha P. ^{[5
]}

Eder, Josie ^{[5
]}

Kim, Young-Mo ^{[5
]}

Gao, Yuqian ^{[5
]}

Fillmore, Thomas L. ^{[15
]}

Zhao, Rui ^{[5
]}

Monroe, Matthew E. ^{[5
]}

Southard-Smith, Austin N. ^{[1
,2
]}

Li, Yang E. ^{[17
,18
]}

Lu, Rita Jui-Hsien ^{[1
,2
]}

Johnson, Jared L. ^{[7
]}

Wiznerowicz, Maciej ^{[19
,20
]}

机构：

[1] Washington Univ St Louis, Dept Med, St. Louis, MO 63110 USA

[2] Washington Univ St Louis, McDonnell Genome Inst, St. Louis, MO 63108 USA

[3] Josep Carreras Leukaemia Res Inst, Badalona, Spain

[4] Univ Autonoma Barcelona, Barcelona 08193, Spain

[5] Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA 99354 USA

[6] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[7] Weill Cornell Med, Meyer Canc Ctr, New York, NY 10021 USA

[8] Weill Cornell Med, Englander Inst Precis Med, Inst Computat Biomed, New York, NY 10021 USA

[9] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY 10032 USA

[10] Univ Penn, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA

[11] Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA

[12] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[13] Washington Univ St Louis, Siteman Canc Ctr, St. Louis, MO 63130 USA

[14] Washington Univ St Louis, Dept Neurol, St. Louis, MO 63130 USA

[15] Spectrum Hlth & Helen DeVos Childrens Hosp, Dept Pathol, Grand Rapids, MI USA

[16] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA

[17] Washington Univ, Sch Med, Dept Genet, St. Louis, MO 63110 USA

[18] Washington Univ, Sch Med, Dept Neurosurg, St. Louis, MO 63110 USA

[19] Int Inst Mol Oncol, Poznan, Poland

[20] Poznan Univ Med Sci, Poznan, Poland

[21] Van Andel Res Inst, Grand Rapids, MI USA

[22] ICF, 530 Gaither Rd,Suite 500, Rockville, MD 20850 USA

[23] NCI, Ctr Biomed Informat & Informat Technol, Div Canc Epidemiol & Genet, Bethesda, MD 20850 USA

[24] NYU, Inst Syst Genet, Grossman Sch Med, New York, NY 10016 USA

[25] NYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10016 USA

[26] NCI, Off Canc Clin Prote Res, Rockville, MD 20850 USA

[27] Frederick Natl Lab Canc Res, Frederick, MD 21701 USA

[28] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[29] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02215 USA

[30] Univ Miami, Miller Sch Med, Dept Neurol Surg, Dept Biochem, Miami, FL 33136 USA

[31] Univ Miami, Sylvester Comprehens Canc Ctr, Miller Sch Med, Miami, FL 33136 USA

[32] Univ Penn, Perelman Sch Med, Dept Pathol, Philadelphia, PA 19104 USA

[33] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21287 USA

[34] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21287 USA

[35] Childrens Hosp Philadelphia, Ctr Data Driven Discovery Biomed, Philadelphia, PA 19104 USA

[36] Childrens Hosp Philadelphia, Div Neurosurg, Philadelphia, PA 19104 USA

[37] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97221 USA

来源：

CANCER CELL | 2024年 / 42卷 / 07期

基金：

美国国家卫生研究院;

关键词：

COPY-NUMBER ALTERATION; READ ALIGNMENT; PROTEIN; CANCER; DATABASE; QUANTIFICATION; GLIOBLASTOMA; PHOSPHATASE; MUTATIONS; RESOURCE;

D O I：

10.1016/j.ccell.2024.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas.

引用

页码：1217 / 1238.e19

页数：42

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