Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis

被引：0

作者：

Margoni, Margoni ^{[1
,2
,3
]}

Preziosa, Paolo ^{[1
,2
,4
]}

Pagani, Elisabetta ^{[1
]}

Storelli, Loredana ^{[1
]}

Gueye, Mor ^{[1
,2
,4
]}

Moiola, Lucia ^{[2
]}

Filippi, Massimo ^{[1
,2
,3
,4
,5
]}

Rocca, Maria A. ^{[1
,2
,4
]}

机构：

[1] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy

[2] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy

[3] IRCCS San Raffaele Sci Inst, Neurorehabil Unit, Milan, Italy

[4] Univ Vita Salute San Raffaele, Milan, Italy

[5] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Milan, Italy

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2024年 / 11卷 / 11期

关键词：

BRAIN-LESIONS;

D O I：

10.1002/acn3.52208

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had >= 3 CVS+ WMLs or >= 1 PRL, whereas 17 (77%) had >= 6 CVS+ WMLs or >= 1 PRL. A simplified CVS-based approach, with the combined evaluation of >= 1 PRL in patients with >= 6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.

引用

页码：3031 / 3036

页数：6

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