TRIM Proteins and Antiviral Microtubule Reorganization: A Novel Component in Innate Immune Responses?

被引：0

作者：

Vadon, Charlotte ^{[1
]}

Magiera, Maria Magda ^{[2
]}

Cimarelli, Andrea ^{[1
]}

机构：

[1] Univ Claude Bernard Lyon 1, Univ Lyon, Ctr Int Rech Infectiol CIRI, Inserm,U1111,CNRS,UMR5308,ENS Lyon, F-69364 Lyon, France

[2] Ctr Univ, Inst Curie, CNRS, UMR3348, Bat 110, F-91405 Orsay, France

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 08期

关键词：

TRIM; cytoskeleton; microtubule; interferon; virus; infection; OPITZ-SYNDROME GENE; E3 UBIQUITIN LIGASE; PHOSPHATASE; 2A; DYNAMIC INSTABILITY; BINDING PROTEIN; G/BBB SYNDROME; SHORT ISOFORM; MID1; GENE; VIRUS; HIV-1;

D O I：

10.3390/v16081328

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TRIM proteins are a family of innate immune factors that play diverse roles in innate immunity and protect the cell against viral and bacterial aggression. As part of this special issue on TRIM proteins, we will take advantage of our findings on TRIM69, which acts by reorganizing the microtubules (MTs) in a manner that is fundamentally antiviral, to more generally discuss how host-pathogen interactions that take place for the control of the MT network represent a crucial facet of the struggle that opposes viruses to their cell environment. In this context, we will present several other TRIM proteins that are known to interact with microtubules in situations other than viral infection, and we will discuss evidence that may suggest a possible contribution to viral control. Overall, the present review will highlight the importance that the control of the microtubule network bears in host-pathogen interactions.

引用

页数：21

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