Higher Dietary Polyphenol Intake Is Associated With Lower Blood Inflammatory Markers

Background: Evidence suggests a link between polyphenol intake and reduced incidence of several chronic diseases. This could arise through associations between polyphenol intake and reduced systemic oxidative stress and subsequent inflammation. fl ammation. However, confirming fi rming this association is difficult, fi cult, as few large cohorts allow for comprehensive assessments of both polyphenol intake and markers of systemic inflammation. fl ammation. Objectives: To address this, polyphenol intake was assessed in the UK-based Airwave cohort using 7-d diet diaries and data from Phenol- Explorer to test for associations between polyphenol intake and blood biomarkers of inflammation. fl ammation. Methods: Participants included 9008 males and females aged 17-74 - 74 y (median age: 42 y) whose data was included in a cross-sectional analysis. Phenol-Explorer was used to estimate individuals' ' polyphenol intake from diet data describing the consumption of 4104 unique food items. C-reactive protein (CRP) and fi brinogen were used as blood biomarkers of inflammation. fl ammation. Results: There were 448 polyphenols found in reported diet items. Median total polyphenol intake was 1536 mg/d (1058-2092 - 2092 mg/d). Phenolic acids and fl avonoids were the main types of polyphenols, and nonalcoholic beverages, vegetables, and fruit were the primary sources. Variation in energy-adjusted polyphenol intake was explained by age, sex, salary, body mass index, education level, smoking, and alcohol consumption. Linear regressions showed inverse associations between total daily intake and both CRP ((3: (3 :- 0.00702; P < 0.001) and fi brinogen ((3: (3 :- 0.00221; P = 0.038). Associations with specific fi c polyphenol compound groups were also found. Logistic regressions using total polyphenol intake quartiles showed stepwise reductions in the odds of elevated CRP with higher intake (6%, 23%, and 24% compared with quartile 1; P = 0.003), alongside 3% and 7% lower odds per unit of polyphenol consumption equivalent to 1 cup of tea or coffee per day. Conclusions: This study describes polyphenol intake in a large, contemporary UK cohort. We observed associations between higher intake and lower CRP and fi brinogen. This contributes to evidence supporting the health benefits fi ts of dietary polyphenols.