Sepia pharaonis Ink Mitigates Dehydroepiandrosterone-Induced Insulin Resistance in Mouse Model of Polycystic Ovarian Syndrome

被引:1
|
作者
Yamarthi, Prathyusha [1 ]
Kotipalli, Rama Satyasri [2 ]
Patnaik, Samatasai [2 ]
Veena, K. V. [1 ]
Kathirvel, Muralidharan [2 ]
Vutukuri, Rajkumar [3 ]
Bhanoori, Manjula [1 ]
机构
[1] Osmania Univ, Dept Biochem, Hyderabad 500007, India
[2] CSIR Indian Inst Chem Technol, Appl Biol, Hyderabad 500007, India
[3] Goethe Univ Frankfurt, Pharmazentrum Frankfurt, Inst Gen Pharmacol & Toxicol, D-60596 Frankfurt, Germany
关键词
Sepia pharaonis ink; PCOS; insulin resistance; DHEA; RT-PCR; metformin; FATTY LIVER-DISEASE; WOMEN; CELLS;
D O I
10.3390/pathophysiology31030031
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The present study aims to evaluate the effect of Sepia pharaonis ink on insulin resistance in PCOS-induced mice. Treatment with sepia ink in dehydroepiandrosterone (DHEA)-induced PCOS mice at various doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg body weight mitigated the insulin resistance in the study groups with decreased concentration of testosterone and increased concentrations of estrogen and progesterone compared to the PCOS group tested by ELISA. The histopathological analysis and restoration of glucose analysis showed a significant reduction in treatment groups. Reduced expression of insulin resistance genes like androgen receptor (AR), insulin receptor substrate 1 (IRS-1), and insulin-like growth factor1 (IGF-1) by qRT-PCR indicate a positive impact of sepia ink in alleviating the symptoms associated with PCOS. Taken together, the results of this study indicate sepia ink as a promising therapeutic intervention and a possible drug target for insulin resistance in diabetes and gynecological disorders like PCOS.
引用
收藏
页码:408 / 419
页数:12
相关论文
共 50 条
  • [21] Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults
    Huang, Ying
    Gao, Jiang-Man
    Zhang, Chun-Mei
    Zhao, Hong-Cui
    Zhao, Yue
    Li, Rong
    Yu, Yong
    Qiao, Jie
    REPRODUCTION, 2016, 152 (06) : 705 - 714
  • [22] Investigation of the Protective Effect of Nerolidol on Dehydroepiandrosterone-induced Polycystic Ovary Syndrome in Female Rats
    Yuce, Hande
    Turkmen, Nese Basak
    Aydin, Muhterem
    Taslidere, Asli
    Dogan, Aysegul
    Ozek, Dilan Askin
    Hayal, Taha Bartu
    Yasar, Seyma
    Ciftci, Osman
    Unuvar, Songul
    ACTA PHYSIOLOGICA, 2023, 237 : 37 - 37
  • [23] Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome
    Verit, Fatma Ferda
    FERTILITY AND STERILITY, 2009, 91 (06) : E2 - E2
  • [24] Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome
    Brennan, Kathleen
    Huang, Andy
    Azziz, Ricardo
    FERTILITY AND STERILITY, 2009, 91 (05) : 1848 - 1852
  • [25] Polycystic ovarian syndrome (PCOS) and insulin resistance
    Park, KH
    Kim, JY
    Ahn, CW
    Song, YD
    Lim, SK
    Lee, HC
    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2001, 74 (03) : 261 - 267
  • [26] INSULIN-RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME
    DUNAIF, A
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 687 : 60 - 64
  • [27] Vitamin E modulates androgen receptor gene expression to attenuate ovarian dysfunctions in a rat model of dehydroepiandrosterone-induced polycystic ovary
    Olaniyan, Olugbemi T.
    Dare, Ayobami
    Adetunji, Charles O.
    Okotie, Gloria E.
    Dare, Joseph B.
    Adigun, Bosun M.
    Adebayo, Femi
    ASIAN PACIFIC JOURNAL OF REPRODUCTION, 2023, 12 (02) : 81 - 89
  • [28] Chinese medicine compound prescription HeQi San ameliorates chronic inflammatory states and modulates gut flora in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model
    Li, Juntong
    Liu, Deliang
    Zhao, Hengxia
    Zhang, Pengxiang
    Cai, Fangying
    Li, Huilin
    Chu, Shufang
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 137
  • [29] Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome Reply
    Brennan, Kathleen
    Huang, Andy
    Azziz, Ricardo
    FERTILITY AND STERILITY, 2009, 91 (06) : E3 - E3
  • [30] The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance
    Kajita, K
    Ishizuka, T
    Miura, A
    Ishizawa, M
    Kanoh, Y
    Yasuda, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 277 (02) : 361 - 367