Optogenetic Vision Restoration

被引：3

作者：

Busskamp, Volker ^{[1
]}

Roska, Botond ^{[2
,3
]}

Sahel, Jose-Alain ^{[4
,5
]}

机构：

[1] Univ Hosp Bonn, Degenerat Retinal Dis, D-53127 Bonn, Germany

[2] Inst Mol & Clin Ophthalmol Basel, CH-4031 Basel, Switzerland

[3] Univ Basel, Dept Ophthalmol, CH-4001 Basel, Switzerland

[4] Univ Pittsburgh, UPMC Vis Inst, Dept Ophthalmol, Sch Med, Pittsburgh, PA 15213 USA

[5] Sorbonne Univ, Quinze Vingts Hop Vis, Inst Hosp Univ FOReSIGHT, Inserm, F-75012 Paris, France

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2024年 / 14卷 / 08期

关键词：

RESTORES VISUAL RESPONSES; RETINAL BIPOLAR CELLS; LIGHT-DRIVEN PROTON; ADENOASSOCIATED VIRUS; ECTOPIC EXPRESSION; CHANNELRHODOPSIN-2; DEGENERATION; TRANSDUCTION; STIMULATION; SENSITIVITY;

D O I：

10.1101/cshperspect.a041660

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Optogenetics has emerged over the past 20 years as a powerful tool to investigate the various circuits underlying numerous functions, especially in neuroscience. The ability to control by light the activity of neurons has enabled the development of therapeutic strategies aimed at restoring some level of vision in blinding retinal conditions. Promising preclinical and initial clinical data support such expectations. Numerous challenges remain to be tackled (e.g., confirmation of safety, cell and circuit specificity, patterns, intensity and mode of stimulation, rehabilitation programs) on the path toward useful vision restoration.

引用

页数：10

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