Evaluation of morphology, physical and mechanical properties of hyaluronic acid matrices of various molecular weights by atomic force microscopy

被引：0

作者：

Kuznetsova, Tatyana ^{[1
]}

Lapitskaya, Vasilina ^{[1
]}

Chizhik, Sergei ^{[1
]}

Aizikovich, Sergei ^{[2
]}

Nikolaev, Andrey ^{[2
]}

Sadyrin, Evgeniy ^{[2
]}

Liudchyk, Andrei ^{[3
]}

Swain, Michael, V ^{[2
,4
]}

机构：

[1] AV Luikov Heat & Mass Transfer Inst Natl Acad Sci, Lab Nanoproc & Technol, 15 P Brovki St, Minsk 220072, BELARUS

[2] Don State Tech Univ, Res & Educ Ctr Mat, 1 Gagarin Sq, Rostov Na Donu 344003, Russia

[3] LLC Co HyalSyn Technol, Minsk, BELARUS

[4] Univ Sydney, Fac Dent, Biomat & Bioengn Dept, Sydney, NSW 2006, Australia

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2024年 / 412卷

基金：

俄罗斯科学基金会;

关键词：

Hyaluronic acid; Proteoglycan aggregate; Matrix; Atomic force microscopy; Elastic modulus; Adhesion; ELASTIC-MODULUS; HYDROGELS; INDENTATION; PROBE; MUCOPOLYSACCHARIDES; RELIABILITY; ACCURACY; TISSUE;

D O I：

10.1016/j.molliq.2024.125833

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Using atomic force microscopy the morphology of 1 and 2 % sodium hyaluronate solutions matrix with low molecular weight (LM) and high molecular weight (HM) hyaluronic acid (HA) fabricated by bioenzymatic synthesis was evaluated. The presence of a proteoglycan aggregate with processes of the core protein in the absence of sulfated glycosaminoglycans was established. The effect of irradiation with a light flux on the ordering of the HA matrix was observed. Intermolecular consolidation of high molecular HA was established. The elastic modulus of the matrix with LM and HM HA has also been determined.

引用

页数：10

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