TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/β-Catenin Signaling Pathway

被引：1
|
作者：
Huang, Xiuyan [1 ]
Li, Qing [1 ]
Zheng, Xiaoxia [1 ]
Jiang, Chen [1 ]
机构：
[1] Jinan Matern & Child Care Hosp, Dept Gynaecol, 2 Jianguo Xiao Jingsan Rd Jinan, Jinan 250001, Shandong, Peoples R China
来源：
CANCER INVESTIGATION | 2024年 / 42卷 / 08期
关键词：
TTYH3; Wnt/beta-catenin signaling; cervical cancer; TWEETY; HOMOLOG; GENE;
D O I：
10.1080/07357907.2024.2395014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of tweety homolog 3 (TTYH3) has been studied in several cancers, including hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer. The results showed that TTYH3 is highly expression in cervical cancer tissues and cells and high TTYH3 expression correlates with poor prognosis in patients with cervical cancer. TTYH3 markedly reduced the apoptosis rate and promoted proliferation, migration, and invasion. Silencing of TTYH3 has been shown to have an inhibitory effect on cervical cancer progression. Moreover, TTYH3 enhanced EMT and activated Wnt/beta-catenin signaling. Furthermore, TTYH3 knockdown inhibited the tumor growth in vivo. In conclusion, TTYH3 promoted cervical cancer progression by activating the Wnt/beta-catenin signaling.
引用
收藏
页码：726 / 739
页数：14
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