Selective Oxidation of Benzo[d]isothiazol-3(2H)-Ones Enabled by Selectfluor

被引：0

作者：

Li, Qin ^{[1
]}

Yuan, Dan ^{[1
]}

Liu, Chong ^{[2
]}

Herington, Faith ^{[2
]}

Yang, Ke ^{[1
]}

Ge, Haibo ^{[2
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

[2] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

MOLECULES | 2024年 / 29卷 / 16期

关键词：

Selectfluor; oxidation; benzoisothiazol-3-one-1-oxide; DERIVATIVES;

D O I：

10.3390/molecules29163899

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A metal-free and Selectfluor-mediated selective oxidation reaction of benzo[d]isothiazol-3(2H)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[d]isothiazol-3(2H)-one-1-oxides with excellent yields and high tolerance to various functional groups. Furthermore, the purification of benzoisothiazol-3-one-1-oxides does not rely on column chromatography. Moreover, the preparation of saccharine derivatives has been achieved through sequential, double oxidation reactions in a one-pot aqueous media.

引用

页数：15

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