Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial

被引:0
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作者
Verhaar, Barbara J. H. [1 ,3 ,4 ]
Wijdeveld, Madelief [1 ,4 ,5 ]
Wortelboer, Koen [2 ,4 ,5 ]
Rampanelli, Elena [2 ,4 ,5 ,6 ]
Levels, Johannes H. M. [2 ]
Collard, Didier [1 ]
Cammenga, Marianne [1 ]
Nageswaran, Vanasa [7 ]
Haghikia, Arash [7 ,8 ,9 ]
Landmesser, Ulf [7 ,8 ,9 ]
Li, Xinmin S. [10 ]
Didonato, Joseph A. [10 ]
Hazen, Stanley L. [11 ]
Garrelds, Ingrid M. [12 ]
Danser, A. H. Jan [12 ]
van den Born, Bert-Jan H. [1 ,4 ,13 ]
Nieuwdorp, Max [1 ,4 ]
Muller, Majon [3 ,4 ]
机构
[1] Amsterdam UMC, Dept Vasc Med, Locat AMC, POB 22660, NL-1100 DD Amsterdam, Netherlands
[2] Amsterdam UMC Locat AMC, Expt Vasc Med, Amsterdam, Netherlands
[3] Amsterdam UMC Locat VUmc, Dept Internal Med Geriatr, Amsterdam, Netherlands
[4] Amsterdam Cardiovasc Sci Diabet & Metab Atheroscle, Amsterdam, Netherlands
[5] Univ Amsterdam, Amsterdam Gastroenterol Endocrinol Metab, Amsterdam UMC, Amsterdam, Netherlands
[6] Amsterdam Inst Infect & Immun, Infect Dis, Canc Immunol, Amsterdam, Netherlands
[7] Deutsch Herzzentrum Charite, Dept Cardiol Angiol & Intens Care Med, Campus Benjamin Franklin, Berlin, Germany
[8] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany
[9] Charite Univ Med Berlin Inst Hlth, Friede Springe Cardiovasc Prevent Ctr Charite, Berlin, Germany
[10] Cleveland Clin, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA
[11] Cleveland Clin, Heart Vasc & Thorac Inst, Dept Cardiovasc Med, Cleveland, OH USA
[12] Erasmus MC, Dept Internal Med, Div Pharmacol, Rotterdam, Netherlands
[13] Amsterdam UMC, Dept Publ & Occupat Med, Amsterdam, Netherlands
关键词
blood pressure; butyric acid; feces; gastrointestinal microbiome; humans; hypertension; CHAIN FATTY-ACIDS; II-INDUCED HYPERTENSION; GUT MICROBIOTA; T-CELL; SODIUM; ACTIVATION; RECEPTOR; SUPPLEMENTATION; INFLAMMATION; METABOLITES;
D O I
10.1161/HYPERTENSIONAHA.123.22437
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
BACKGROUND: The microbiota-derived short chain fatty acid butyrate has been shown to lower blood pressure (BP) in rodent studies. Nonetheless, the net effect of butyrate on hypertension in humans remains uncovered. In this study, for the first time, we aimed to determine the effect of oral butyrate on BP in patients with hypertension. METHODS: We performed a double-blind randomized placebo-controlled trial including 23 patients with hypertension. Antihypertensive medication was discontinued for the duration of the study with a washout period of 4 weeks before starting the intervention. Participants received daily oral capsules containing either sodium butyrate or placebo with an equivalent dosage of sodium chloride for 4 weeks. The primary outcome was daytime 24-hour systolic BP. Differences between groups over time were assessed using linear mixed models (group-by-time interaction). RESULTS: Study participants (59.0 +/- 3.7 years; 56.5% female) had an average baseline office systolic BP of 143.5 +/- 14.6 mm Hg and diastolic BP of 93.0 +/- 8.3 mm Hg. Daytime 24-hour systolic and diastolic BP significantly increased over the intervention period in the butyrate compared with the placebo group, with an increase of +9.63 (95% CI, 2.02-17.20) mm Hg in daytime 24-hour systolic BP and +5.08 (95% CI, 1.34-8.78) mm Hg in diastolic BP over 4 weeks. Butyrate levels significantly increased in plasma, but not in feces, upon butyrate intake, underscoring its absorption. CONCLUSIONS: Four-week treatment with oral butyrate increased daytime systolic and diastolic BP in subjects with hypertension. Our findings implicate that butyrate does not have beneficial effects on human hypertension, which warrants caution in future butyrate intervention studies.
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页码:2124 / 2136
页数:13
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