The Intestinal Microbiota and Therapeutic Responses to Immunotherapy

被引：0

作者：

Herrera, Pamela S. ^{[1
,3
]}

van den Brink, Marcel ^{[2
,3
]}

机构：

[1] Weill Cornell Med Coll, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplantat Serv, New York, NY USA

[3] Sloan Kettering Inst, Dept Immunol, New York, NY 10065 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY | 2024年 / 8卷

关键词：

microbiota; immunotherapy; allogeneic hematopoietic cell transplantation; allo-HCT; immune checkpoint inhibitors; CAR T cell therapy; dysbiosis; CHAIN FATTY-ACIDS; GUT MICROBIOTA; T-CELLS; METABOLITES; HEALTH; SUSCEPTIBILITY; HEMATOPOIESIS; RESISTANCE; TRANSPLANT; DIVERSITY;

D O I：

10.1146/annurev-cancerbio-062722-035210

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The intestinal microbiota, a complex ecosystem of microorganisms, has emerged as an important player in modulating various aspects of human health and disease. The microbiota is in a state of constant cross talk with itself and its host, and these interactions regulate several aspects of host homeostasis, including immune responses. Studies have demonstrated a relationship between the microbiota and outcomes of several cancer immunotherapies. This review explores the different roles of intestinal microbiota in shaping the efficacy and safety of cancer immunotherapies, including allogeneic hematopoietic cell transplantation, immune checkpoint blockade, and CAR T cell therapy.

引用

页码：435 / 452

页数：18

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