Simple Summary Apart from skin cancer, prostate cancer is the most prevalent cancer in men. The treatment options typically entail active surveillance, surgery, radiation, or a combination of the above. The treatment options for recurrent disease also include surgery, radiation, and focal therapy. In this review, we look at the use of cryoablation for recurrent prostate cancer following radiation treatment.Abstract The treatment options for prostate cancer typically entail active surveillance, surgery, radiation, or a combination of the above. Disease recurrence remains a concern, with a wide range of recurrence rates having been reported in the literature. In the setting of recurrence, the salvage treatment options include salvage prostatectomy, salvage high-intensity focused ultrasound (HIFU), stereotactic body radiotherapy (SBRT), salvage brachytherapy, and salvage cryoablation. In this review, we analyze the currently available data related to salvage cryoablation for recurrent prostate cancer following radiation.