Acute Effects of Steroids on Vocal Fold Epithelium Post-injury in a Preclinical Model

被引：0

作者：

Gartling, Gary ^{[1
]}

Sayce, Lea ^{[2
]}

Zimmerman, Zachary ^{[3
]}

Slater, Alysha ^{[2
]}

Hary, Lizzie ^{[2
]}

Yang, Wenqing ^{[4
]}

Santacatterina, Michele ^{[4
]}

Rousseau, Bernard ^{[5
]}

Branski, Ryan C. ^{[1
]}

机构：

[1] NYU Grossman Sch Med, Dept Otolaryngol Head & Neck Surg, New York, NY USA

[2] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Commun Sci & Disorders, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA USA

[4] NYU Grossman Sch Med, Dept Populat Hlth, Div Biostat, New York, NY USA

[5] St Louis Univ, Doisy Coll Hlth Sci, St Louis, MO USA

来源：

LARYNGOSCOPE | 2024年

关键词：

laryngology; molecular biology/vocal fold would healing; vocal fold - basic science; VOICE DISORDERS; IN-VITRO; GLUCOCORTICOIDS; INJECTION; PERMEABILITY; MECHANISMS; INTEGRITY; INHIBITION; RECOVERY; DISEASE;

D O I：

10.1002/lary.31729

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glucocorticoids (GCs) are commonly prescribed for laryngeal indications due to their potent anti-inflammatory properties, but effects on vocal fold (VF) epithelial morphology and barrier function following injury is overlooked. Acutely, GCs did not alter TEER and did not alter epithelial depth compared to saline treatment, indicating alignment with natural healing responses. At 60-days, GCs exhibited varying degrees of TEER restoration and epithelial hyperplasia, possibly due to distinct pharmacodynamic profiles.image

引用

页数：7

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