Generation of a human induced pluripotent stem cell line ZZUNEUi030-A from a female patient carrying a heterozygous CALM2 (c.395 A > T) mutation

被引：0
|
作者：
Hua, Chongpei [1 ]
Sun, Wenrui [1 ]
Zhang, Chunjin [1 ]
Tian, Xiaoxu [1 ]
Qin, Xintong [1 ]
Dong, Jianzeng [1 ,2 ]
Li, Xiaowei [1 ]
机构：
[1] Zhengzhou Univ, Ctr Cardiovasc Dis, Affiliated Hosp 1, Henan Key Lab Hereditary Cardiovasc Dis, Zhengzhou 450052, Peoples R China
[2] Capital Med Univ, Beijing Anzhen Hosp, Natl Clin Res Ctr Cardiovasc Dis, Dept Cardiol, 2 Beijing Anzhen Rd, Beijing 100029, Peoples R China
来源：
STEM CELL RESEARCH | 2024年 / 81卷
基金：
中国博士后科学基金;
关键词：
D O I：
10.1016/j.scr.2024.103515
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Calmodulin mutations can cause life-threatening long QT syndrome involving CALM1, CALM2, and CALM3. In this study, human induced pluripotent stem cells ZZUNEUi030-A were derived from a female patient with heterozygous CALM2 gene c. 395A -> T by Sendai virus non-integrated reprogramming technology. The cell line showed a normal female karyotype (46, XX), expressed pluripotency markers, and had the ability to differentiate into three germ layers in vitro. ZZUNEUi030-A can be used as a cell disease model to study the pathogenesis of LQT caused by calmodulin mutations.
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页数：5
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