The numerical and experimental research of rotating detonation engines is usually conducted in ground environmental conditions. Although many breakthroughs have been made, there are still deficiencies in understanding engines operating in real flight conditions. In order to reveal the effect of engine size and initial kerosene droplet size on the rotating detonation engines in flight conditions, the Eulerian-Lagrangian model is adopted, and a series of two-phase kerosene/air rotating detonation cases are simulated in the conditions of Mach 5 and 24 km altitude. When 5 mu m and 10 mu m droplets are adopted, the RDE behaves like gaseous rotating detonations with clear cellular structures. When the 20 mu m and 30 mu m droplets are adopted, the rotating detonation waves tend to be divided into two layers and form the 2-shaped shock structure. The results indicate that droplet size and engine size influence detonation wave propagation and flow field mainly through droplet heat absorption and evaporation height. Increasing the engine sizes can promote the two-phase rotating detonation and broaden the initial diameter range capable of obtaining rotating detonation waves. However, as droplet size increases, the fresh mixture layer becomes stratified, with an upper layer predominantly comprising fuel vapor and a lower layer of fuel droplets, which results in an 2-shaped shock structure at the detonation front. The flight operation condition brings in differences in features such as detonation wave height and velocity deficit. The detonation height in flight conditions is higher than that in ground conditions. The most velocity deficit in flight conditions observed in our study is below 15 %, which is lower than the results (22.5 %) in ground operating conditions. These results indicate that the optimal design of the rotating detonation engine must consider the real operation conditions and the effect of engine sizes and droplet sizes.