Antimutagenic and Cytotoxic Potential of Punica granatum L. and Opuntia ficusindica L. Peels

被引：1
|
作者：
El Sawi, Salma A. [1 ]
Elbatanony, Marwa M. [1 ]
El-Feky, Amal M. [1 ]
Farghaly, Ayman A. [2 ]
机构：
[1] Natl Res Ctr, Pharmacognosy Dept, 33El Buhouth St, Cairo 12622, Egypt
[2] Natl Res Ctr, Genet & Cytol Dept, 33El Bohouth St, Cairo 12622, Egypt
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2024年 / 67卷 / 01期
关键词：
Punica granatum; Opuntia ficus-indica; betanin; triterpenes; cytotoxic; antimutagenic; POMEGRANATE; ANTIOXIDANT; TRITERPENES; FLAVONOIDS; CANCER; ACID; PREVENTION; EXTRACTS;
D O I：
10.21608/EJCHEM.2023.218408.8158
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study was designed to validate the phytochemistry and the antimutagenic activity of two common plant peels; Punica granatum L. and Opuntia ficus-indica L. HPLC analysis revealed that P. granatum peels comprised mainly of 16 flavonoids and 18 phenolics; the most predominant flavonoid and phenolic were hesperidin and pyrogallol, respectively, while Opuntia ficus-indica L. composed of 18 flavonoids and 10 phenolics. The main flavonoid and phenolic compounds were kaempferol-3, 7-dirhamnoside and quinic, respectively. Compounds; alpha larabinofuranosyl (3-D-glucopyranoside (4), punicaflavanol (5), and two hydrolyzable tannins (6&7) were isolated from P. granatum, while friedelin (8), 24-methylene-ergosta-5-en-3(3-ol (9), apigenin-7-O-glucoside (10), isorhamnetin 3-O-(3-D-glucopyranoside (11), and betanin (12) were isolated from O. ficus-indica. The antioxidant and cytotoxic studies revealed that P. granatum peel extract has relatively significant effects on the tested cancer cell lines, while that of O. ficus-indica peels showed potent cytotoxic activity against HCT-9 and HEPG2. The antimutagenicity study emphasized their ability to repair the genotoxic effect of the anticancer drug cyclophosphamide.
引用
收藏
页码：267 / 283
页数：17
相关论文
共 50 条
  • [31] Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent against Different Cancer Cell Lines
    Keta, Otilija
    Deljanin, Milena
    Petkovic, Vladana
    Zdunic, Gordana
    Jankovic, Teodora
    Zivkovic, Jelena
    Ristic-Fira, Aleksandra
    Petrovic, Ivan
    Savikin, Katarina
    RECORDS OF NATURAL PRODUCTS, 2020, 14 (05) : 326 - 339
  • [32] Antifungal activity of acetone extracts from Punica granatum L., Quercus suber L. and Vicia faba L.
    Akroum, S.
    JOURNAL DE MYCOLOGIE MEDICALE, 2017, 27 (01): : 83 - 89
  • [33] THE ROLE OF POMEGRANATE (PUNICA GRANATUM L.) IN COLON CANCER
    Khan, Seher A.
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 22 (03) : 346 - 348
  • [34] Comparison of in vitro regeneration pathways in Punica granatum L.
    Kanwar, Kamlesh
    Joseph, Jomy
    Deepika, Raj
    PLANT CELL TISSUE AND ORGAN CULTURE, 2010, 100 (02) : 199 - 207
  • [35] Acclimatization of in vitro cultured pomegranate (Punica granatum L.)
    Patil, K. B.
    Patil, J.
    Moharir, K.
    Patil, A. B.
    Jangale, B. L.
    Krishna, B.
    XXXI INTERNATIONAL HORTICULTURAL CONGRESS, IHC2022: INTERNATIONAL SYMPOSIUM ON IN VITRO TECHNOLOGY AND MICROPROPAGATED PLANTS, 2023, 1359 : 95 - 103
  • [36] Pomegranate (Punica granatum L.) Genetic Diversity in Azerbaijan
    Akparov, Z. I.
    Bayramova, D. B.
    Mustafayeva, Z. P.
    Babayeva, S. M.
    Mammadov, A. T.
    III INTERNATIONAL SYMPOSIUM ON POMEGRANATE AND MINOR MEDITERRANEAN FRUITS, 2015, 1089 : 253 - 256
  • [37] Pomegranate (Punica granatum L.) in Florida: A disease snapshot
    Kc, A. N.
    Vallad, G. E.
    PHYTOPATHOLOGY, 2015, 105 (04)
  • [38] Antiplasmodial activity of Punica granatum l. fruit rind
    Dell'Agli, M.
    Galli, G. V.
    Corbett, Y.
    Lucantoni, L.
    Habluetzel, A.
    Maschi, O.
    Caruso, D.
    Giavarini, F.
    Romeo, S.
    Bosisio, E.
    Taramelli, D.
    TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2009, 14 : 129 - 129
  • [39] Albania, the domestication country for pomegranate (Punica granatum L.)
    Xhuveli, Lufter
    GENETIC RESOURCES AND CROP EVOLUTION, 2012, 59 (08) : 1605 - 1610
  • [40] Status of Pomegranate (Punica granatum L.) Cultivation in Afghanistan
    Samadi, G. R.
    II INTERNATIONAL SYMPOSIUM ON POMEGRANATE AND MINOR - INCLUDING MEDITERRANEAN - FRUITS: ISPMMF2009, 2011, 890 : 55 - 59
12345