Advancements in electrochemical immunosensors towards point-of-care detection of cardiac biomarkers

被引:2
|
作者
Madhurantakam, Sasya [1 ]
David, Bianca Elizabeth [1 ]
Naqvi, Aliya [1 ]
Lee, Zachary J. [1 ]
Abraham, Jacob Thomas [1 ]
Vankamamidi, Trayi Sai [1 ]
Prasad, Shalini [1 ]
机构
[1] Univ Texas Dallas, Dept Bioengn, 800W Campbell Rd, Richardson, TX 75080 USA
关键词
C-REACTIVE PROTEIN; TROPONIN-I; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; GOLD NANOPARTICLES; CARBON NANOTUBES; SELECTIVE IMMUNOSENSOR; EARLY-DIAGNOSIS; GRAPHENE OXIDE; MYOGLOBIN;
D O I
10.1039/d4ay01049c
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Cardiovascular disease remains the leading cause of death worldwide, with mortality rates increasing annually. This underscores the urgent need for accurate diagnostic and monitoring tools. Electrochemical detection has emerged as a promising method for swiftly and precisely measuring specific biomarkers in bodily fluids. This approach is not only cost-effective and efficient compared to traditional clinical methods, but it can also be tailored to detect individual biomarkers, which makes it particularly well-suited for point-of-care (POC) applications. The ability to conduct testing at the point of care is crucial for timely interventions and personalized disease management, empowering healthcare providers to tailor treatment plans based on real-time biomarker data. Thanks to recent advancements in nanomaterials, we've seen significant progress in electrochemical detection, leading to the development of specialized rapid immunoassay systems. These systems utilize specific antibodies to target molecules, expanding the range of detectable biomarkers. This innovation has the potential to revolutionize the diagnosis and treatment of cardiovascular diseases by enhancing detection sensitivity and specificity. Ultimately, these advancements aim to improve patient outcomes by enabling earlier diagnosis, more precise monitoring, and personalized therapeutic interventions, which will contribute to more effective management of cardiovascular health globally. Cardiac biomarkers and their connection to cardiovascular diseases.
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页数:20
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