PREDICTION OF HUMAN CLEARANCE USING HUMAN LIVER MICROSOMES AND HEPATOCYTES WITH 455 DRUGS

被引：0
|
作者：
Tess, David [1 ]
Chang, George [2 ]
Keefer, Christopher [2 ]
Carlo, Anthony [2 ]
Jones, Rhys [3 ]
Di, Li [2 ]
机构：
[1] Pfizer Inc, Cambridge, MA USA
[2] Pfizer Inc, Groton, CT USA
[3] Pfizer Inc, La Jolla, CA USA
来源：
DRUG METABOLISM AND PHARMACOKINETICS | 2024年 / 55卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P8
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver
    Al-Jahdari, Wael S.
    Yamamoto, Koujirou
    Hiraoka, Haruhiko
    Nakamura, Katsunori
    Goto, Fumio
    Horiuchi, Ryuya
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (07) : 527 - 533
  • [22] Predictions of the In Vivo Clearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations
    Michael A. Mohutsky
    Jenny Y. Chien
    Barbara J. Ring
    Steven A. Wrighton
    Pharmaceutical Research, 2006, 23 : 654 - 662
  • [23] Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations
    Mohutsky, MA
    Chien, JY
    Ring, BJ
    Wrighton, SA
    PHARMACEUTICAL RESEARCH, 2006, 23 (04) : 654 - 662
  • [24] Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology
    Wood, F. L.
    Houston, J. B.
    Hallifax, D.
    DRUG METABOLISM AND DISPOSITION, 2017, 45 (11) : 1178 - 1188
  • [25] Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs
    Palacharla, Veera Raghava Chowdary
    Nirogi, Ramakrishna
    Kumar, Nitesh
    Nandakumar, Krishnadas
    EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2025, 50 (02) : 119 - 135
  • [26] Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma
    Jialin Mao
    Suzanne Tay
    Cyrus S. Khojasteh
    Yuan Chen
    Cornelis E. C. A. Hop
    Jane R. Kenny
    Pharmaceutical Research, 2016, 33 : 1204 - 1219
  • [27] Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma
    Mao, Jialin
    Tay, Suzanne
    Khojasteh, Cyrus S.
    Chen, Yuan
    Hop, Cornelis E. C. A.
    Kenny, Jane R.
    PHARMACEUTICAL RESEARCH, 2016, 33 (05) : 1204 - 1219
  • [28] Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
    Di, Li
    Keefer, Christopher
    Scott, Dennis O.
    Strelevitz, Timothy J.
    Chang, George
    Bi, Yi-An
    Lai, Yurong
    Duckworth, Jonathon
    Fenner, Katherine
    Troutman, Matthew D.
    Obach, R. Scott
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 57 : 441 - 448
  • [29] Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes
    Bachmann, K
    Byers, J
    Ghosh, R
    XENOBIOTICA, 2003, 33 (05) : 475 - 483
  • [30] Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines
    Hallifax, D
    Rawden, HC
    Hakooz, N
    Houston, JB
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (12) : 1852 - 1858
12345