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- [41] Discovery of novel 7,8-dihydropteridine-6(5H)-one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategyEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 237Ding, Zongbao论文数: 0 引用数: 0 h-index: 0机构: Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R ChinaPan, Wei论文数: 0 引用数: 0 h-index: 0机构: South China Univ Technol, Affiliated Hosp 6, Nanhai Peoples Hosp, Dept Cardiol, Foshan 528200, Guangdong, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R ChinaXiao, Yao论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ Sci & Technol, Wuhan Wuchang Hosp, Wuchang Hosp, Wuchang 430063, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R ChinaCheng, Binbin论文数: 0 引用数: 0 h-index: 0机构: Hubei Polytech Univ, Sch Med, Hubei Key Lab Kidney Dis Pathogenesis & Intervent, Huangshi 435003, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R ChinaHuang, Gang论文数: 0 引用数: 0 h-index: 0机构: Shantou Univ, Yuebei Peoples Hosp, Dept Hematol, Med Coll, 51200, Shaoguan, Guangdong, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R ChinaChen, Jianjun论文数: 0 引用数: 0 h-index: 0机构: Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg & Guangdong Prov Key Lab Precis Med, Guangzhou 510515, Guangdong, Peoples R China Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai 519041, Peoples R China
- [42] Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl} prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activityBIOORGANIC & MEDICINAL CHEMISTRY, 2022, 71Imaizumi, Tomoyoshi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanAkaiwa, Michinori论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanAbe, Tomoaki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNigawara, Takahiro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKoike, Takanori论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanSatake, Yoshiki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanWatanabe, Kazushi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKaneko, Osamu论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanAmano, Yasushi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanMori, Kenichi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanYamanaka, Yosuke论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNagashima, Takeyuki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanShimazaki, Masashi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKuramoto, Kazuyuki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan
- [43] Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl} prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumorsBIOORGANIC & MEDICINAL CHEMISTRY, 2024, 98Imaizumi, Tomoyoshi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Discovery Accelerator, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanShimada, Itsuro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanSatake, Yoshiki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanYamaki, Susumu论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKoike, Takanori论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNigawara, Takahiro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKaneko, Osamu论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanAmano, Yasushi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanMori, Kenichi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanYamanaka, Yosuke论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNakayama, Ayako论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNishizono, Yoshihiro论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanShimazaki, Masashi论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanNagashima, Takeyuki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, JapanKuramoto, Kazuyuki论文数: 0 引用数: 0 h-index: 0机构: Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Astellas Pharma Inc, Tsukuba Res Ctr, 21,Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan