A comprehensive analysis of the role of cuproptosis in periodontitis through integrated analysis of single-cell and bulk RNA sequencing

被引：0
|
作者：
Fu, Yuanyuan [1 ,2 ]
Zhong, Chongbin [1 ]
Cui, Junhe [1 ,2 ]
Xie, Shengjie [1 ,2 ]
Guo, Chuang [1 ,2 ]
机构：
[1] Northeastern Univ, Coll Life & Hlth Sci, Key Lab Bioresource Res & Dev Liaoning Prov, Shenyang, Peoples R China
[2] Northeastern Univ, Inst Neurosci, Coll Life & Hlth Sci, Shenyang 110819, Peoples R China
来源：
ARCHIVES OF MEDICAL SCIENCE | 2024年 / 20卷 / 04期
关键词：
periodontitis; cuproptosis; single-cell sequence; DISEASE;
D O I：
10.5114/amos/192414
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Trace mineral micronutrients are essential for periodontal health, and unbalanced levels of trace minerals are related to chronic periodontitis, including copper. We attempted to explore the relationship between cuproptosis and periodontitis. Methods: Bulk RNA-seq and single-cell RNA sequencing data were used to analyze expression of cuproptosis-related genes (CRGs) in periodontitis. A mouse periodontitis model was established to verify the expression of key genes. Results: Cuproptosis-related genes were differentially expressed in periodontitis. RT-PCR results confirmed the alteration of five key genes in the mouse model. Conclusions: Cuproptosis is an important player in the pathophysiological process of periodontitis.
引用
收藏
页数：9
相关论文
共 50 条
  • [41] Integrated single-cell and bulk RNA sequencing analysis identifies a prognostic signature related to ferroptosis dependence in colorectal cancer
    Xu, Xiaochen
    Zhang, Xinwen
    Lin, Qiumei
    Qin, Yuling
    Liu, Yihao
    Tang, Weizhong
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [42] Integrated analysis of fibroblasts molecular features in papillary thyroid cancer combining single-cell and bulk RNA sequencing technology
    Li, Wei
    Liu, Zhiyong
    Cen, Xiaoxia
    Xu, Jing
    Zhao, Suo
    Wang, Bin
    Zhang, Wei
    Qiu, Ming
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [43] Integrated single-cell and bulk RNA sequencing analysis identified pyroptosis-related signature for diagnosis and prognosis in osteoarthritis
    Yanzhong Chen
    Yaonan Zhang
    Yongwei Ge
    Hong Ren
    Scientific Reports, 13
  • [44] Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing
    Heng, Jacob S.
    Hackett, Sean F.
    Stein-O'Brien, Genevieve L.
    Winer, Briana L.
    Williams, John
    Goff, Loyal A.
    Nathans, Jeremy
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (52) : 26734 - 26744
  • [45] Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses
    Tzec-Interian, Jorge A.
    Gonzalez-Padilla, Daianna
    Gongora-Castillo, Elsa B.
    QUANTITATIVE BIOLOGY, 2025, 13 (02)
  • [46] Complex Analysis of Single-Cell RNA Sequencing Data
    Khozyainova, Anna A. A.
    Valyaeva, Anna A. A.
    Arbatsky, Mikhail S. S.
    Isaev, Sergey V. V.
    Iamshchikov, Pavel S. S.
    Volchkov, Egor V. V.
    Sabirov, Marat S. S.
    Zainullina, Viktoria R. R.
    Chechekhin, Vadim I. I.
    Vorobev, Rostislav S. S.
    Menyailo, Maxim E. E.
    Tyurin-Kuzmin, Pyotr A. A.
    Denisov, Evgeny V. V.
    BIOCHEMISTRY-MOSCOW, 2023, 88 (02) : 231 - 252
  • [47] Complex Analysis of Single-Cell RNA Sequencing Data
    Anna A. Khozyainova
    Anna A. Valyaeva
    Mikhail S. Arbatsky
    Sergey V. Isaev
    Pavel S. Iamshchikov
    Egor V. Volchkov
    Marat S. Sabirov
    Viktoria R. Zainullina
    Vadim I. Chechekhin
    Rostislav S. Vorobev
    Maxim E. Menyailo
    Pyotr A. Tyurin-Kuzmin
    Evgeny V. Denisov
    Biochemistry (Moscow), 2023, 88 : 231 - 252
  • [48] Comparative Analysis of Single-Cell - RNA Sequencing Methods
    Ziegenhain, C.
    Vieth, B.
    Parekh, S.
    Reinius, B.
    Guillaumet-Adkins, A.
    Smets, M.
    Leonhardt, H.
    Heyn, H.
    Hellmann, I.
    Enard, W.
    ANNALS OF HEMATOLOGY, 2017, 96 : S58 - S58
  • [49] Comparative Analysis of Single-Cell RNA Sequencing Methods
    Ziegenhain, Christoph
    Vieth, Beate
    Parekh, Swati
    Reinius, Bjorn
    Guillaumet-Adkins, Amy
    Smets, Martha
    Leonhardt, Heinrich
    Heyn, Holger
    Hellmann, Ines
    Enard, Wolfgang
    MOLECULAR CELL, 2017, 65 (04) : 631 - +
  • [50] From bulk, single-cell to spatial RNA sequencing
    Xinmin Li
    Cun-Yu Wang
    International Journal of Oral Science, 2021, 13 (04) : 339 - 344
12345