Flavonoids from Rhodiola fastigiata and their Antimalarial Activities

被引：1
|
作者：
Liu, Bo-Chao [1 ,2 ,3 ]
Gou, Liang [1 ,2 ,3 ]
Sun, He [1 ,2 ,3 ]
Zhou, Guo-Jun [1 ,2 ,3 ]
Li, Gang [1 ,2 ,3 ]
Xiao, Chao-Jiang [1 ,2 ,3 ]
Shen, Lei [1 ,2 ,3 ]
Jiang, Bei [1 ,2 ,3 ]
机构：
[1] Dali Univ, Yunnan Key Lab Screening & Res Anti Pathogen Plant, Dali 671000, Peoples R China
[2] Dali Univ, Inst Mat Med, Dali 671000, Peoples R China
[3] Dali Univ, Coll Pharm, Dali 671000, Peoples R China
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2024年 / 34卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Crassulaceae; Flavonoids; Structural elucidation; Antimalarial activity;
D O I：
10.1007/s43450-024-00581-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new flavonoid glycoside, herbacetin-8-O-methyl glucuronide, together with nine known flavonoids herbacetin-8-O-beta-d-xylopyranoside, kaempferol, herbacetin-8-methylether, naringenin, tricin, aromadendrin, quercetin, myricetin, and 5,7,3',4',5'-pentahydroxy-flavanone, was isolated from Rhodiola fastigiata (Hook.f. & Thomson) Fu, Crassulaceae. Their structures were identified by comprehensive analyses of physicochemical properties and spectrometric data (NMR and HR-ESI-MS). According to the bioactive study, herbacetin-8-O-beta-d-xylopyranoside showed significant in vitro antimalarial activity against Plasmodium falciparum 3D7 at 50 mu M. Further studies indicated that herbacetin-8-O-beta-d-xylopyranoside was able to reduce the mitochondrial membrane potential of P. falciparum 3D7 considerably.
引用
收藏
页码：1377 / 1381
页数：5
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