Wall Shear Stress (WSS) Analysis in Atherosclerosis in Partial Ligated Apolipoprotein E Knockout Mouse Model through Computational Fluid Dynamics (CFD)

被引:0
|
作者
Cho, Minju [1 ]
Hwang, Joon Seup [1 ]
Kim, Kyeong Ryeol [1 ]
Kim, Jun Ki [1 ,2 ]
机构
[1] Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
[2] Asan Med Ctr, Asan Inst Life Sci, Biomed Engn Res Ctr, Seoul 05505, South Korea
基金
新加坡国家研究基金会;
关键词
atherosclerosis; plaque formation; computational fluid dynamics (CFD); wall shear stress (WSS); ApoE-KO mice; standard deviation; ENDOTHELIAL-CELLS; BLOOD-FLOW; INFLAMMATION; MECHANISMS; ARTERIES; RISK;
D O I
10.3390/ijms25189877
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis involves an inflammatory response due to plaque formation within the arteries, which can lead to ischemic stroke and heart disease. It is one of the leading causes of death worldwide, with various contributing factors such as hyperlipidemia, hypertension, obesity, diabetes, and smoking. Wall shear stress (WSS) is also known as a contributing factor of the formation of atherosclerotic plaques. Since the causes of atherosclerosis cannot be attributed to a single factor, clearly understanding the mechanisms and causes of its occurrence is crucial for preventing the disease and developing effective treatment strategies. To better understand atherosclerosis and define the correlation between various contributing factors, computational fluid dynamics (CFD) analysis is primarily used. CFD simulates WSS, the frictional force caused by blood flow on the vessel wall with various hemodynamic changes. Using apolipoprotein E knockout (ApoE-KO) mice subjected to partial ligation and a high-fat diet at 1-week, 2-week, and 4-week intervals as an atherosclerosis model, CFD analysis was conducted along with the reconstruction of carotid artery blood flow via magnetic resonance imaging (MRI) and compared to the inflammatory factors and pathological staining. In this experiment, a comparative analysis of the effects of high WSS and low WSS was conducted by comparing the standard deviation of time-averaged wall shear stress (TAWSS) at each point within the vessel wall. As a novel approach, the standard deviation of TAWSS within the vessel was analyzed with the staining results and pathological features. Since the onset of atherosclerosis cannot be explained by a single factor, the aim was to find the correlation between the thickness of atherosclerotic plaques and inflammatory factors through standard deviation analysis. As a result, the gap between low WSS and high WSS widened as the interval between weeks in the atherosclerosis mouse model increased. This finding not only linked the occurrence of atherosclerosis to WSS differences but also provided a connection to the causes of vulnerable plaques.
引用
收藏
页数:14
相关论文
共 30 条
  • [21] The Wall Shear Stress of the Pulmonary Arteries in the Patients with Chronic Thromboembolic Pulmonary Hypertension Before and After Balloon Pulmonary Angioplasty; Analysis Using Computational Fluid Dynamics
    Tsubata, H.
    Nakanishi, N.
    Itatani, K.
    Fukai, K.
    Yanishi, K.
    Zen, K.
    Yamano, T.
    Nakamura, T.
    Shiraishi, H.
    Shirayama, T.
    Yaku, H.
    Matoba, S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [22] Investigations Using a Combination of Computational Fluid Dynamics Technique and an Animal Model of Experimentally Induced Cerebral Aneurysms Suggest Important Roles of Wall Shear Stress on the Cerebral Aneurysm Development
    Fukuda, Shunichi
    Shimogonya, Yuji
    Fukuda, Miyuki
    Hasegawa, Koji
    STROKE, 2015, 46
  • [23] The influence of flow distribution strategy for the quantification of pressure- and wall shear stress-derived parameters in the coronary artery: A CTA-based computational fluid dynamics analysis
    Shi, Yibing
    Zheng, Jin
    Zhang, Ying
    Sun, Quanlin
    Shen, Jinhua
    Gao, Yongguang
    Sun, Jingxi
    Yang, Ning
    Zhou, Xuanxuan
    Li, Suqing
    Weir-McCall, Jonathan R.
    Xia, Ping
    Teng, Zhongzhao
    JOURNAL OF BIOMECHANICS, 2023, 161
  • [24] Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
    LaDisa, John F., Jr.
    Olson, Lars E.
    Hettrick, Douglas A.
    Warltier, David C.
    Kersten, Judy R.
    Pagel, Paul S.
    BIOMEDICAL ENGINEERING ONLINE, 2005, 4 (1)
  • [25] Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
    John F LaDisa
    Lars E Olson
    Douglas A Hettrick
    David C Warltier
    Judy R Kersten
    Paul S Pagel
    BioMedical Engineering OnLine, 4
  • [26] High Wall Shear Stress Is Related to Atherosclerotic Plaque Rupture in the Aortic Arch of Patients with Cardiovascular Disease: A Study with Computational Fluid Dynamics Model and Non-Obstructive General Angioscopy
    Kojima, Keisuke
    Hiro, Takafumi
    Koyama, Yutaka
    Ohgaku, Akihito
    Fujito, Hidesato
    Ebuchi, Yasunari
    Arai, Riku
    Monden, Masaki
    Migita, Suguru
    Morikawa, Tomoyuki
    Tamaki, Takehiro
    Murata, Nobuhiro
    Akutsu, Naotaka
    Nishida, Toshihiko
    Kitano, Daisuke
    Sudo, Mitsumasa
    Fukamachi, Daisuke
    Yoda, Shunichi
    Takayama, Tadateru
    Hirayama, Atsushi
    Okumura, Yasuo
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2021, 28 (07) : 742 - 753
  • [27] Impact of Wall Shear Stress on Aortic Plaque Rupture Within Aortic Arch Assessed by Computational Fluid Dynamics Model Derived in Three Dimensional CT Angiography and Non-Obstructive Aortic Angioscopy
    Kojima, Keisuke
    Hiro, Takafumi
    Morikawa, Tomoyuki
    Migita, Suguru
    Tamaki, Takehiro
    Mineki, Takashi
    Akutsu, Naotaka
    Murata, Nobuhiro
    Sudo, Mitsumasa
    Kitano, Daisuke
    Fukamachi, Daisuke
    Takayama, Tadateru
    Hirayama, Atsushi
    Okumura, Yasuo
    CIRCULATION, 2018, 138
  • [28] Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
    John F LaDisa
    Lars E Olson
    Hettrick A Douglas
    David C Warltier
    Judy R Kersten
    Paul S Pagel
    BioMedical Engineering OnLine, 5
  • [29] Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
    LaDisa, John F., Jr.
    Olson, Lars E.
    Douglas, Hettrick A.
    Warltier, David C.
    Kersten, Judy R.
    Pagel, Paul S.
    BIOMEDICAL ENGINEERING ONLINE, 2006, 5 (1)
  • [30] Predicting hemodynamics in native and residual coarctation: preliminary results of a Rigid-Wall Computational-Fluid-Dynamics model (RW-CFD) validated against clinically invasive pressure measures at rest and during pharmacological stress
    Israel Valverde
    Cristina Staicu
    Heynric Grotenhuis
    Alberto Marzo
    Kawal Rhode
    Yubing Shi
    Alistair G Brown
    Aphrodite Tzifa
    Tarique Hussain
    Gerald Greil
    Patricia Lawford
    Reza Razavi
    Rod Hose
    Philipp Beerbaum
    Journal of Cardiovascular Magnetic Resonance, 13 (Suppl 1)