A critical role for palmitoylation in pyroptosis

被引：1
|
作者：
Sun, Zhiqi [1 ,2 ]
Hornung, Veit [1 ,2 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Gene Ctr, Butenandtstr 1, D-81377 Munich, Germany
[2] Ludwig Maximilians Univ Munchen, Dept Biochem, Butenandtstr 1, D-81377 Munich, Germany
来源：
MOLECULAR CELL | 2024年 / 84卷 / 12期
关键词：
GASDERMIN D;
D O I：
10.1016/j.molcel.2024.05.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three recent publications by Du et al.,1 1 Balasubramanian et al.,2 2 and Zhang et al.3 3 identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.
引用
收藏
页码：2218 / 2220
页数：3
相关论文
共 50 条
  • [31] The role of palmitoylation in regulating Ras localization and function
    Eisenberg, Sharon
    Laude, Alex J.
    Beckett, Alison J.
    Mageean, Craig J.
    Aran, Veronica
    Hernandez-Valladares, Maria
    Henis, Yoav I.
    Prior, Ian A.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2013, 41 : 79 - 83
  • [32] S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane
    Jiang, Min
    Hu, Junping
    White, Frances K. H.
    Williamson, Judy
    Klymchenko, Andrey S.
    Murthy, Akshay
    Workman, Samuel W.
    Tseng, Gea-Ny
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (36) : 13487 - 13501
  • [33] Determining the role of palmitoylation in subcellular localization of ankyrins
    Jenkins, P.
    Philippe, J.
    JOURNAL OF NEUROCHEMISTRY, 2019, 150 : 50 - 51
  • [34] THE DYNAMIC ROLE OF PALMITOYLATION IN SIGNAL-TRANSDUCTION
    MILLIGAN, G
    PARENTI, M
    MAGEE, AI
    TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (05) : 181 - 186
  • [35] Protein palmitoylation is critical for the polar growth of root hairs in Arabidopsis
    Yu-Ling Zhang
    En Li
    Qiang-Nan Feng
    Xin-Ying Zhao
    Fu-Rong Ge
    Yan Zhang
    Sha Li
    BMC Plant Biology, 15
  • [36] Protein palmitoylation is critical for the polar growth of root hairs in Arabidopsis
    Zhang, Yu-Ling
    Li, En
    Feng, Qiang-Nan
    Zhao, Xin-Ying
    Ge, Fu-Rong
    Zhang, Yan
    Li, Sha
    BMC PLANT BIOLOGY, 2015, 15
  • [37] The Critical Role of Inflammasome Induced GSDMD-Dependent Pyroptosis for Acinar Cell Death in Acute Pancreatitis
    Gao, L.
    Huang, W.
    Xue, J.
    Ke, L.
    Gao, X.
    Tong, Z.
    Lu, G.
    Li, W.
    PANCREAS, 2019, 48 (10) : 1430 - 1430
  • [38] Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking
    Ren, Wenying
    Sun, Yingmin
    Du, Keyong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 460 (03) : 709 - 714
  • [39] The Role of Pyroptosis and Autophagy in the Nervous System
    Huijie Zhao
    Xiaodi Fu
    Yanting Zhang
    Chaoran Chen
    Honggang Wang
    Molecular Neurobiology, 2024, 61 : 1271 - 1281
  • [40] The Role of Autophagy and Pyroptosis in Liver Disorders
    Zhao, Huijie
    Liu, Huiyang
    Yang, Yihan
    Wang, Honggang
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)
12345