Leveraging genetic data to improve the care of patients with thoracic aortic dilation

被引：1
|
作者：
DePaolo, John [1 ]
Zhang, David Y. [2 ]
Damrauer, Scott M. [2 ,3 ,4 ,5 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Surg, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Dept Surg, Div Vasc Surg, 3400 Civ Ctr Dr,14th Floor South Perelman Ctr, Philadelphia, PA 19104 USA
[4] Univ Penn, Perelman Sch Med, Dept Med, Cardiovasc Inst, Philadelphia, PA 19104 USA
[5] Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA 19104 USA
来源：
EUROPEAN HEART JOURNAL | 2024年 / 45卷 / 40期
关键词：
DIAMETER;
D O I：
10.1093/eurheartj/ehae499
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Potential future implementation of the AORTA Gene model to improve the treatment of individuals with thoracic aortic disease. The AORTA Gene model is derived from the integration of a polygenic score for ascending aortic diameter into the clinical AORTA Score. AORTA Gene can potentially be applied to determine patients who warrant screening for thoracic aortic dilation. In the future it is hoped that similar models will be able to be inform who may benefit from aggressive medical management or earlier elective surgical intervention based on individual-level risk. This figure was generated with Biorender.com [GRAPHICS]
引用
收藏
页码：4333 / 4335
页数：3
相关论文
共 50 条
  • [1] Characterization of the Rate of Aortic Dilation in Young Patients with Thoracic Aortic Aneurysm
    Wheeler, Adam P.
    Yang, Ziyi
    Cordes, Timothy M.
    Markham, Larry W.
    Landis, Benjamin J.
    PEDIATRIC CARDIOLOGY, 2021, 42 (01) : 148 - 157
  • [2] Characterization of the Rate of Aortic Dilation in Young Patients with Thoracic Aortic Aneurysm
    Adam P. Wheeler
    Ziyi Yang
    Timothy M. Cordes
    Larry W. Markham
    Benjamin J. Landis
    Pediatric Cardiology, 2021, 42 : 148 - 157
  • [3] Molecular and Genetic insights into Thoracic Aortic Dilation in Conotruncal Heart Defects
    Kay, W. Aaron
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2016, 3
  • [4] Association of left ventricular hypertrophy and aortic dilation in patients with acute thoracic aortic dissection
    Iarussi, D
    Caruso, A
    Galderisi, M
    Covino, FE
    Dialetto, G
    Bossone, E
    de Divitiis, O
    Cotrufo, M
    ANGIOLOGY, 2001, 52 (07) : 447 - 455
  • [5] Bovine aortic arch: A novel association with thoracic aortic dilation
    Malone, C. D.
    Urbania, T. H.
    Crook, S. E. S.
    Hope, M. D.
    CLINICAL RADIOLOGY, 2012, 67 (01) : 28 - 31
  • [6] Thoracic Aortic Dilation/Aneurysm in Fabry Disease
    Dormond, Olivier
    Barbey, Frederic
    AMERICAN JOURNAL OF MEDICINE, 2013, 126 (12): : E23 - E23
  • [7] Incidental Thoracic Aortic Dilation on Chest Computed Tomography in Patients With Atrial Fibrillation
    Ramchand, Jay
    Bansal, Agam
    Bin Saeedan, Mnahi
    Wang, Tom Kai Ming
    Agarwal, Ritu
    Kanj, Mohamed
    Wazni, Oussama
    Svensson, Lars G.
    Desai, Milind Y.
    Harb, Serge C.
    Schoenhagen, Paul
    Burrell, Louise M.
    Griffin, Brian P.
    Popovic, Zoran B.
    Kalahasti, Vidyasagar
    AMERICAN JOURNAL OF CARDIOLOGY, 2021, 140 : 78 - 82
  • [8] Leveraging Digital Data to Inform and Improve Quality Cancer Care
    Hernandez-Boussard, Tina
    Blayney, Douglas W.
    Brooks, James D.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2020, 29 (04) : 816 - 822
  • [9] YIELD OF GENETIC TESTING IN PATIENTS WITH THORACIC AORTIC DISEASE
    Mazine, Amine
    Moryousef-Abitbol, Joseph H.
    Faghfoury, Hanna
    Meza, James M.
    Morel, Chantal
    Ouzounian, Maral
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (11) : 2005 - 2005
  • [10] Implications of aortic neck dilation following thoracic endovascular aortic repair
    Ahmad, Wael
    Weidler, Paula
    Salem, Oroa
    Werra, Ursula
    Majd, Payman
    Dorweiler, Bernhard
    JOURNAL OF VASCULAR SURGERY, 2023, 78 (06) : 1402 - 1408.e1
12345