Synthesis of indolyl pyrroloindolines via a cascade arylation/cyclization of indole acetamides with 3-substituted indoles

被引：0

作者：

Zhang, Wei ^{[1
]}

Han, Shuai ^{[1
]}

Zhang, Si-Yi ^{[1
]}

Jiang, Dong-Xiao ^{[1
]}

Chen, Jinjin ^{[1
]}

Wang, Zhen ^{[1
]}

Zeng, Yao-Fu ^{[1
]}

机构：

[1] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 18期

基金：

中国国家自然科学基金;

关键词：

CONSTRUCTION; ALKALOIDS; AMAUROMINE; CATIONS;

D O I：

10.1039/d4qo01118j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel TEA-mediated cascade arylation/cyclization reaction between indole acetamides and 3-substituted indoles has been developed. This method allows the synthesis of various indolyl pyrroloindolines in good yields under metal- and photocatalyst-free conditions. A gram-scale experiment and further derivatization of the products demonstrated the potential value of our method.

引用

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页码：5167 / 5171

页数：5

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