Terpenoids from the rhizomes of Curcuma kwangsiensis SG Lee et CF Ling and their anti-inflammatory activities

被引:0
|
作者
Zhang, Qingqing [1 ]
Xu, Yang [1 ]
Sun, Yanyu [1 ]
Dong, Huiying [1 ]
Sun, Dejuan [1 ]
Li, Hua [1 ,2 ]
Chen, Lixia [1 ]
机构
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Inst Struct Pharmacol & TCM Chem Biol, Coll Pharm, Fuzhou 350122, Peoples R China
基金
中国国家自然科学基金;
关键词
Curcuma kwangsiensis S. G. Lee et C. F. Liang; Terpenoids; Anti-inflammatory activity; NITRIC-OXIDE PRODUCTION; CHEMICAL-CONSTITUENTS; INHIBITORY-ACTIVITIES; SESQUITERPENES; PHAEOCAULIS; WENYUJIN; ANTIBACTERIAL; ETHER;
D O I
10.1016/j.fitote.2024.106137
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Three new sesquiterpenes, 4S-1-(3-hydroxybutyl)-7-(11-hydroxypropyl)-10-methyl- cyclohepta-7,5,10-trien-8one (1), 8R-hydroxy-7-(4S-4,10-dimethyl-5-oxooct-1-en-7-yl)-11- methylfuran-12-one (2), (1S,5R,7S,10R)-1hydroxy-7-(11-hydroxypropyl)-10-methyl-4- methyleneoctahydronaphthalen-8-one (3), along with 30 known terpenoids (4-33) were obtained from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling. Through comprehensive analysis of chemical evidence and spectral data including UV, ECD, IR, 1D and 2D NMR and HRESI-MS, as well as quantum chemical calculation, the structures of these novel compounds were successfully determined. Additionally, the inhibitory effects of compounds 1-2, 4-33 on NO production were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells. Notably, compound 33 exhibited the most significant inhibitory effect with an IC50 value of 3.55 +/- 0.55 mu M.
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页数:7
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