Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021-June 2023

被引：0

作者：

Almendares, Olivia ^{[1
]}

Baker, Julia M. ^{[1
]}

Sugerman, David E. ^{[1
]}

Parashar, Umesh D. ^{[1
]}

Reagan-Steiner, Sarah ^{[1
]}

Kirking, Hannah L. ^{[1
]}

Gastanaduy, Paul A. ^{[1
]}

Tate, Jacqueline E. ^{[1
]}

机构：

[1] CDCP, 1600 Clifton Rd NE,Mailstop H24-9, Atlanta, GA 30329 USA

来源：

EMERGING INFECTIOUS DISEASES | 2024年 / 30卷 / 04期

关键词：

ACUTE LIVER-FAILURE; ADENOVIRUS INFECTION; CHILDREN; PCR;

D O I：

10.3201/eid3004.231140

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During October 2021-June 2023, a total of 392 cases of acute hepatitis of unknown etiology in children in the United States were reported to Centers for Disease Control and Prevention as part of national surveillance. We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance of continued investigation to determine the mechanism of liver injury and appropriate treatment. Testing for adenovirus in similar cases could elucidate the role of the virus.

引用

页码：644 / 653

页数：10