Green Synthesis of Bimetallic Cu-Cd Nanoparticles and its Catalytic Activity in Pyrido [2,3-d;6,5-d] Dipyrimidine Derivatives

Green synthesis nanoparticles have gained interest in recent years due to their environmental friendliness and sustainability. The current study focuses on the green synthesis of BMNP using spearmint leaves as a reducing and stabilizing agent. Because of their excellent catalytic characteristics, the synthesized bimetallic nanoparticles function as an effective catalyst in pyrido[2,3-d:6,5-d] pyrimidine derivatives. The synthesized nanoparticles are characterized using a variety of techniques, including FT-IR analysis, SEM & EDX, XRD, and TEM. The FT-IR study shows a reduction in functional groups in the leaf extract, confirming the metal nanoparticles' stretching. SEM and EDX studies confirm the shape and elemental composition of bimetallic nanoparticles. XRD investigation showed that the synthesized NPs are crystalline, and the Scherrer equation was used to calculate the average crystallite size. The calculated size was 49 nm. TEM analysis confirms the core-shell nature of BMNPs. The synthesized nanoparticles acted as a superior catalyst in pyrido[2,3-d:6,5-d] dipyrimidines derivatives. in the synthetic procedure, BMNPs enhanced the catalytic activity and reduced the reaction time with more yield, Compared to the previous study. and the synthesized compound [1-5] has been confirmed by FT-IR, 1H-NMR, and 13C-NMR analysis. and it has given better results in in-vivo anti-diabetic activity by Streptozotocin nicotinamide. This induced model adult male albino Wistar derivatives show significant fasting blood glucose levels when compared to metformin hydrochloride. and its evaluated molecular docking study, exhibit excellent CDDOCKER energy. The green synthesis of Cu-Cd bimetallic nanoparticles synthesized by mangrove plant Excoecaria agallocha. Synthesized BMNP nanoparticles are used as an effective catalyst in pyrido[2,3-d;6,5-d'] dipyrimidine derivatives. The synthesized derivative compounds tested for anti-diabetic and molecular docking studies. image