Use of Collagen Powder in Secondary Intention Healing After Mohs Surgery or Excisional Surgery: A Retrospective Study

Background. Little is known about the usefulness of collagen powder in secondary intention healing in patients undergoing cutaneous surgery. Objective. To investigate the clinical outcomes associated with application of collagen powder in cutaneous surgery and patients' perceptions of the procedure. Methods. A retrospective chart review of 266 patients who underwent Mohs surgery or excisional surgery at a single institution between January 2020 and January 2022, and who had secondary intention healing of wounds assisted by powdered collagen was conducted. Personal interviews were conducted with 63 of those patients (23.7%). Tumor characteristics, estimated healing times, and patient satisfaction were scored. The Vancouver Scar Scale and the Patient and Observer Scar Assessment Scale were used to assess the resulting wound bed. All data underwent statistical analysis. Results. Of 266 granulating wounds with an average defect size of 6.0 cm2, excisional surgery was performed in 143 (54%) and Mohs surgery in 123 (46%). Most procedures (92.1%) were undertaken for nonmelanoma skin cancers. The average healing time was 6.3 weeks. The mean patient score for ease of use and overall impression of collagen application was 8.2 on a scale of 1 to 10, with 10 being most favorable. Conclusion. When clinically appropriate, granulation assisted by collagen powder should be considered for augmenting secondary intention healing.