Phytochemical Research and Anti-Inflammatory Activities of the Ethanol Extract from Anoectochilus Roxburghii (Wall.) Lindl

被引：0
|
作者：
Yao, Guang-Xiao [1 ,2 ]
Zhang, Jian [3 ,4 ]
Wu, Mei [5 ]
Yao, Zhi-Ren [1 ,2 ]
Huang, Ya-Ping [1 ,2 ]
Mu, Long [1 ,2 ]
Wang, Lei [1 ,2 ]
Pan, Ke [1 ,2 ]
Yin, Zhi-Qi [1 ,2 ]
Song, Zhe [1 ,2 ]
机构：
[1] Sch Tradit Chinese Pharm, Nanjing 211198, Peoples R China
[2] China Pharmaceut Univ, Ctr Anal & Testing, Nanjing 211198, Peoples R China
[3] Nanjing Lishui Dist Hosp Tradit Chinese Med, Nanjing 211200, Peoples R China
[4] Nanjing Univ Chinese Med, Afiliated Hosp Integrated Tradit Chinese & Western, Nanjing 210028, Peoples R China
[5] Jinhua Acad Agr Sci, Jinhua 321017, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 09期
关键词：
Anoectochilus roxburghii; anti-inflammatory activity; ethanol extracts; Orchidaceae; CHEMICAL-CONSTITUENTS; KINSENOSIDE; GLYCOSIDES;
D O I：
10.1002/cbdv.202401220
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Anoectochilus roxburghii is a well-known and valuable traditional Chinese herb due to various medicinal and functional benefits. In-depth investigation is necessary to discover active ingredients and expand its application. In this study, four new compounds (1-4) along with ten known compounds (5-14) were isolated from the ethanol extract of A.roxburghii. Their structures were elucidated by spectroscopic data interpretation. The isolates were screened for their inhibitory activities on the production of NO in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Among them, compounds 5, 6, 9, 10, 12, 13 and 14 exhibited significant anti-inflammatory activity through inhibiting the release of NO.
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页数：6
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