Spatial Structure and Anti-Inflammatory Activity of 5-N-Arylaminocarbonyl-6-Aryl-4-Methyl-1,2,3,6-Tetrahydropyrimidine-2-Thiones

被引：0
|
作者：
Buzmakova, N. A. [1 ]
Zamaraeva, T. M. [1 ]
Rudakova, I. P. [1 ]
Dmitriev, M. V. [2 ]
机构：
[1] Perm Pharmaceut Acad, Minist Hlth Russia, 2 Polevaya St, Perm 614990, Russia
[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614990, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 05期
关键词：
5-carbamoylsubstituted dihydropyrimidine-2(1H)-thiones; x-ray diffraction analysis; anti-inflammatory activity; DIHYDROPYRIMIDINONES;
D O I：
10.1007/s11094-024-03201-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-inflammatory activity of 17 derivatives of 5-N-arylaminocarbonyl-6-aryl-4-methyl-1,2,3,6-tetrahydropyrimidine-2-thiones was studied. The molecular structure of one of them was established. Ten compounds that inhibited the inflammatory reaction in experimental animals in the range 56-81% were identified.
引用
收藏
页码：738 / 741
页数：4
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