Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

被引：0

作者：

Pellicci, Daniel G. ^{[1
,2
,3
]}

Tavakolinia, Naeimeh ^{[1
,2
]}

Perriman, Louis ^{[1
,4
,5
]}

Berzins, Stuart P. ^{[2
,5
]}

Menne, Christopher ^{[1
]}

机构：

[1] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[4] Fiona Elsey Canc Res Inst, Ballarat, Vic, Australia

[5] Federat Univ Australia, Ballarat, Vic, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

unconventional T cells; unconventional T cell development; cytokines; cytotoxic granules; immunotherapy; INVARIANT NKT CELLS; TRANSCRIPTION FACTOR PLZF; MONOCLONAL-ANTIBODY; ANTITUMOR-ACTIVITY; HUMAN INKT; LINEAGE; SUBSETS; CD4(+); CD1D; EXPRESSION;

D O I：

10.3389/fimmu.2024.1441634

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invariant natural killer T (iNKT) cells are a subset of lipid-reactive, unconventional T cells that have anti-tumor properties that make them a promising target for cancer immunotherapy. Recent studies have deciphered the developmental pathway of human MAIT and V gamma 9V delta 2 gamma delta-T cells as well as murine iNKT cells, yet our understanding of human NKT cell development is limited. Here, we provide an update in our understanding of how NKT cells develop in the human body and how knowledge regarding their development could enhance human treatments by targeting these cells.

引用

页数：10

共 50 条

[31] Natural killer cells in cancer immunotherapy
Wang, DanRu
Dou, LingYun
Sui, LiHao
Xue, Yiquan
Xu, Sheng
MEDCOMM, 2024, 5 (07):
[32] Cancer immunotherapy with natural killer cells
Herberman, RB
SEMINARS IN ONCOLOGY, 2002, 29 (03) : 27 - 30
[33] Natural killer cells in tumor immunotherapy
Dongyao Wang
Haiming Wei
Cancer Biology & Medicine, 2023, 20 (08) : 539 - 544
[34] Natural killer cells in tumor immunotherapy
Dongyao Wang
Haiming Wei
Cancer Biology & Medicine, 2023, (08) : 539 - 544
[35] NATURAL KILLER T CELLS Switching on human NKT cells
Minton, Kirsty
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (12) : 820+821 - 821
[36] Unraveling natural Killer T-Cells Development
Bennstein, Sabrina Bianca
FRONTIERS IN IMMUNOLOGY, 2018, 8
[37] Natural killer T cells regulate the development of asthma
Pichavant, Muriel
Matangkasombut, Ponpan
DeKruyff, Rosemarie H.
Umetsu, Dale T.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2009, 5 (03) : 251 - 260
[38] Metabolic hallmarks of natural killer cells in the tumor microenvironment and implications in cancer immunotherapy
Yang, Yuqing
Chen, Lin
Zheng, Bohao
Zhou, Shengtao
ONCOGENE, 2023, 42 (01) : 1 - 10
[39] Natural killer T cells regulate the development of asthma
Umetsu, Dale T.
Meyer, Everett H.
DeKruyff, Rosemarie H.
INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2007, 26 (1-2) : 121 - 140
[40] Metabolic hallmarks of natural killer cells in the tumor microenvironment and implications in cancer immunotherapy
Yuqing Yang
Lin Chen
Bohao Zheng
Shengtao Zhou
Oncogene, 2023, 42 : 1 - 10

← 1 2 3 4 5 →