Tumor-associated exosomes in cancer progression and therapeutic targets

被引:1
|
作者
Liu, Xiaomin [1 ,2 ]
Wu, Fan [1 ]
Pan, Wei [1 ]
Liu, Guangchao [2 ]
Zhang, Hui [2 ]
Yan, Dawei [2 ]
Zheng, Saijing [2 ]
Ma, Zhongliang [1 ]
Ren, Xiaojun [3 ]
机构
[1] Shanghai Univ, Sch Life Sci, Lab Noncoding RNA & Canc, Shanghai 200444, Peoples R China
[2] Shanghai New Tobacco Prod Res Inst Co Ltd, Shanghai, Peoples R China
[3] Beijing Univ Technol, Coll Chem & Life Sci, Dept Chem, Beijing 100124, Peoples R China
来源
MEDCOMM | 2024年 / 5卷 / 09期
基金
中国国家自然科学基金;
关键词
cancer progression; regulation; therapeutic targets; tumor-associated exosomes; CELL LUNG-CANCER; PROMOTES TRASTUZUMAB RESISTANCE; EXTRACELLULAR VESICLES; CLINICAL-IMPLICATIONS; NONCODING RNA; DELIVERY; BINDING; GROWTH; CHEMORESISTANCE; TUMORIGENESIS;
D O I
10.1002/mco2.709
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Exosomes are small membrane vesicles that are released by cells into the extracellular environment. Tumor-associated exosomes (TAEs) are extracellular vesicles that play a significant role in cancer progression by mediating intercellular communication and contributing to various hallmarks of cancer. These vesicles carry a cargo of proteins, lipids, nucleic acids, and other biomolecules that can be transferred to recipient cells, modifying their behavior and promoting tumor growth, angiogenesis, immune modulation, and drug resistance. Several potential therapeutic targets within the TAEs cargo have been identified, including oncogenic proteins, miRNAs, tumor-associated antigens, immune checkpoint proteins, drug resistance proteins, and tissue factor. In this review, we will systematically summarize the biogenesis, composition, and function of TAEs in cancer progression and highlight potential therapeutic targets. Considering the complexity of exosome-mediated signaling and the pleiotropic effects of exosome cargoes has challenge in developing effective therapeutic strategies. Further research is needed to fully understand the role of TAEs in cancer and to develop effective therapies that target them. In particular, the development of strategies to block TAEs release, target TAEs cargo, inhibit TAEs uptake, and modulate TAEs content could provide novel approaches to cancer treatment. 1. Generalized the biogenesis, composition, and function of tumor-associated exosomes (TAEs) in cancer progression.2. Highlight potential therapeutic targets of TAEs.3. TAEs are emerging as important mediators of cancer progression and potential therapeutic targets. image
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页数:24
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