Extracellular RNA and Endothelial TLR3 Link Inflammation and Venous Thromboembolism

被引：1
|
作者：
Savino, Luigi [1 ,2 ]
Savino, Marco [1 ,2 ]
Kansakar, Urna [1 ]
Dazzetti, Tommaso [2 ]
Varzideh, Fahimeh [1 ]
Jankauskas, Stanislovas S. [1 ]
Mone, Pasquale [1 ,2 ,3 ]
Santulli, Gaetano [1 ,4 ]
机构：
[1] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Einstein Inst Neuroimmunol & Inflammat INI, Einstein Mt Sinai Diabet Res Ctr ES DRC,Dept Med,D, New York, NY USA
[2] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Campobasso, Italy
[3] Casa Cura Montevergine, Mercogliano, Avellino, Italy
[4] Albert Einstein Coll Med, Einstein Inst Aging Res, Fle Inst Diabet & Metab FIDAM, Dept Mol Pharmacol, New York, NY USA
来源：
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2024年 / 13卷 / 15期
基金：
美国国家卫生研究院;
关键词：
Editorials; CXCL5; DAMP; endothelial dysfunction; eRNA; NF-kappa B; thromboembolism; TLR3;
D O I：
10.1161/JAHA.124.036335
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [41] The Effect of a TLR3 Agonist on Airway Allergic Inflammation and Viral Infection in Immunoproteasome-Deficient Mice
    Schaunaman, Niccolette
    Nichols, Taylor
    Cervantes, Diana
    Hartsoe, Paige
    Ferrington, Deborah A.
    Chu, Hong Wei
    VIRUSES-BASEL, 2024, 16 (09):
  • [42] Human Endometrial Endothelial Cells Generate an Inflammatory and Anti-Viral Response to a TLR3 Agonist
    Krikun, Graciela
    Potter, Julie
    Guller, Seth
    Mor, Gil
    Abrahams, Vikki M.
    REPRODUCTIVE SCIENCES, 2013, 20 (S3) : 100A - 100A
  • [43] Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro
    Bunting, Rachel A.
    Duffy, Karen E.
    Lamb, Roberta J.
    San Mateo, Lani R.
    Smalley, Karen
    Raymond, Holly
    Liu, Xuesong
    Petley, Ted
    Fisher, Jamie
    Beck, Heena
    Flavell, Richard A.
    Alexopoulou, Lena
    Ward, Christine K.
    CELLULAR IMMUNOLOGY, 2011, 267 (01) : 9 - 16
  • [44] The Effect of TLR3 Receptor Priming on TLR 2,4 and 6 Agonist-Induced Inflammation in Placental Explants.
    Anucha, Eberechi
    Rasheed, Zahirrah Begam Mohamed
    Yun, Lee S.
    MacIntyre, David A.
    Bennett, Phillip R.
    Sykes, Lynne
    REPRODUCTIVE SCIENCES, 2017, 24 : 109A - 109A
  • [45] TLR3 Signaling of Human Cerebral Endothelial Cells Inhibits HIV-1 Replication in Macrophages
    Li, Jieliang
    Wang, Yizhong
    Ye, Li
    Wang, Xu
    Gofman, Larisa
    Ho, Wenzhe
    JOURNAL OF NEUROVIROLOGY, 2012, 18 : 61 - 61
  • [46] Mechanical stimulation of toll-like receptor 3 (TLR3) induces reprogramming of fibroblasts towards endothelial cells
    Graber, Michael
    Hirsch, Jakob
    Poelzl, Leo
    Naegele, Felix
    Schweiger, Victor
    Lobenwein, Daniela
    Lener, Daniela
    Kirchmair, Elke
    Bonaros, Nikolaos
    Grimm, Michael
    Gollmann-Tepekoeylue, Can
    Holfeld, Johannes
    WIENER KLINISCHE WOCHENSCHRIFT, 2019, 131 : 253 - 254
  • [47] TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
    Lim, Chan Seok
    Jang, Yoon Ha
    Lee, Ga Young
    Han, Gu Min
    Jeong, Hye Jin
    Kim, Ji Won
    Lee, Jie-Oh
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [48] Double-stranded RNA-mediated TLR3 activation is enhanced by CD14
    Lee, HK
    Dunzendorfer, S
    Soldau, K
    Tobias, PS
    IMMUNITY, 2006, 24 (02) : 153 - 163
  • [49] OXIDATIVE STRESS ENHANCES TLR3 RESPONSE TO DOUBLE-STRANDED RNA IN AIRWAY EPITHELIAL CELLS
    Koarai, Akira
    Sugiura, Hisatoshi
    Yanagisawa, Satoru
    Ichikawa, Tomohiro
    Minakata, Yoshiaki
    Matsunaga, Kazuto
    Hirano, Tsunahiko
    Akamatsu, Keiichiro
    Ichinose, Masakazu
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2010, 22 : S66 - S67
  • [50] Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice
    Zhou, Rongbin
    Wei, Haiming
    Sun, Rui
    Tian, Zhigang
    JOURNAL OF IMMUNOLOGY, 2007, 178 (07): : 4548 - 4556
12345