Azolylphenanthridine-ligated Cu(II) catalyst for electrochemical oxidation of cholesterol in aprotic medium

被引：0
|
作者：
Okhokhonin, Andrei, V [1 ]
Akulov, Alexey A. [1 ]
Izmozherova, Yulia, V [1 ]
Pershin, Andrey A. [1 ]
Tsmokalyuk, Anton N. [1 ]
Svalova, Tatiana S. [1 ]
Sharutin, Vladimir V. [2 ]
Zyryanov, Grigory, V [1 ,3 ]
Chupakhin, Oleg N. [1 ,3 ]
Varaksin, Mikhail V. [1 ,3 ]
Kozitsina, Alisa N. [1 ]
机构：
[1] Ural Fed Univ, 19 Mira Str, Ekaterinburg 620002, Russia
[2] South Ural State Univ, Natl Res Univ, 76 Lenina Ave, Chelyabinsk 454080, Russia
[3] Postovsky Inst Organ Synth, 22 S Kovalevskoy Str, Ekaterinburg 620990, Russia
来源：
INORGANICA CHIMICA ACTA | 2024年 / 572卷
基金：
俄罗斯科学基金会;
关键词：
N-HETEROCYCLIC CARBENE; PHENANTHRIDINE; COMPLEXES; CHEMISTRY;
D O I：
10.1016/j.ica.2024.122305
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of original 6-(azol-1-yl)phenanthridine ligands and a copper(II) complex based on them is reported. Comprehensive studies of the structural, physicochemical, and electrocatalytic properties for the selected 6-(1H-pyrazol-1-yl)phenanthridine-containing H-pyrazol-1-yl)phenanthridine-containing coordination compound have been carried out. The latter has demonstrated pronounced electrochemical and electrocatalytic activities in the enzyme-free cholesterol oxidation in DMSO. A six-stage mechanism including electrocatalytic reduction of cholesterol and subsequent oxidation of its reduction products has been proposed and underpinned by quantum mechanical considerations. Obtained analytical characteristics of the enzyme-free cholesterol oxidation (LoD 0.0032 mM, detectable concentrations 0.01-0.40 mM) open a prospect towards the investigated complexes to be applied as sensitive elements of portable electrochemical platforms for the point-of-care diagnostics.
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页数：8
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