Therapeutic activity of a new KRASG12C inhibitor JMKX001899 in brain metastases: Preclinical models of KRASG12C-mutant non-small cell lung cancer

被引:0
|
作者
He, Danming
Wang, Jie
Zhu, Yixiang
Zhong, Jia
Bai, Hua
机构
[1] Chinese Acad Med Sci, State Key Lab Mol Oncol, CAMS Key Lab Translat Res Lung Canc,Canc Hosp, Natl Canc Ctr,Natl Clin Res Ctr Canc,Dept Med Onc, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp,State Key Lab Mo, Beijing, Peoples R China
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
8630
引用
收藏
页数:1
相关论文
共 50 条
  • [11] Pan-ErbB inhibition enhances activity of KRASG12C inhibitors in preclinical models of KRASG12C mutant cancers
    Robichaux, Jacqulyne P.
    Galan-Cobo, Ana
    Powell, Ried T.
    Gale, Kelly A.
    He, Jun
    Zhang, Fahao
    Nilsson, Monique B.
    Zhang, Xiang
    Sobieski, Mary M.
    Nguyen, Nghi
    Clifford, Stephan C.
    Heymach, John V.
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [12] Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers
    Khan, Husain Yar
    Nagasaka, Misako
    Aboukameel, Amro
    Alkhalili, Osama
    Uddin, Md. Hafiz
    Bannoura, Sahar F.
    Mzannar, Yousef
    Azar, Ibrahim
    Beal, Eliza W.
    Tobon, Miguel E.
    Kim, Steve H.
    Beydoun, Rafic
    Baloglu, Erkan
    Senapedis, William
    El-Rayes, Bassel F.
    Philip, Philip A.
    Mohammad, Ramzi M.
    Shields, Anthony F.
    Al Hallak, Mohammed Najeeb
    Azmi, Asfar S.
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12) : 1422 - 1433
  • [13] KRASG12C G12C Inhibitors in Non-Small Cell Lung Cancer: A Review
    Tang, Min
    Wu, Yijun
    Bai, Xiufeng
    Lu, You
    ONCOTARGETS AND THERAPY, 2024, 17 : 683 - 695
  • [14] A Novel Inhibitor for KRASG12C Mutant Lung Carcinoma
    Khan, H. Y.
    Li, Y.
    Aboukameel, A.
    Mpilla, G.
    Sexton, R.
    Kanbur, T.
    Cetinkaya, H.
    Cagir, A.
    Al-Hallak, M. N.
    Sukari, A.
    Azmi, A. S.
    Nagasaka, M.
    JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (02) : S15 - S15
  • [15] Activity and resistance to KRASG12C G12C inhibitors in non-small cell lung cancer and colorectal cancer
    Ye, Wei
    Lu, Xin
    Qiao, Yue
    Ou, Wen-Bin
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2024, 1879 (03):
  • [16] Incidence of Brain Metastases and Preliminary Evidence of Intracranial Activity With Sotorasib in Patients With KRASG12C-Mutant Non-Small-Cell Lung Cancer
    Lamberti, Giuseppe
    Aizer, Ayal
    Ricciuti, Biagio
    Alessi, Joao V.
    Pecci, Federica
    Tseng, Shu-Chi
    Sholl, Lynette M.
    Nishino, Mizuki
    Awad, Mark M.
    JCO PRECISION ONCOLOGY, 2023, 7
  • [17] Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
    Khawaja, Hajrah
    Briggs, Rebecca
    Latimer, Cheryl H.
    Rassel, Mustasin
    Griffin, Dary
    Hanson, Lyndsey
    Bardelli, Alberto
    Di Nicolantonio, Frederica
    McDade, Simon S.
    Scott, Christopher J.
    Lambe, Shauna
    Maurya, Manisha
    Lindner, Andreas U.
    Prehn, Jochen H. M.
    Sousa, Jose
    Winnington, Chris
    LaBonte, Melissa J.
    Ross, Sarah
    Van Schaeybroeck, Sandra
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (01) : 135 - 149
  • [18] TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC
    Tammaccaro, Salvina Laura
    Prigent, Philippe
    Le Bail, Jean-Christophe
    Dos-Santos, Odette
    Dassencourt, Laurent
    Eskandar, Myriam
    Buzy, Armelle
    Venier, Olivier
    Guillemot, Jean-Claude
    Veeranagouda, Yaligara
    Didier, Michel
    Spanakis, Emmanuel
    Kanno, Tokuwa
    Cesaroni, Matteo
    Mathieu, Stephane
    Canard, Luc
    Casse, Alhassan
    Windenberger, Fanny
    Calvet, Loreley
    Noblet, Laurence
    Sidhu, Sukhvinder
    Debussche, Laurent
    Moll, Jurgen
    Valtingojer, Iris
    PHARMACEUTICALS, 2023, 16 (04)
  • [19] Trials, Tribunals, and Opportunities for Lung Cancer KRASG12C Brain Metastases
    Kommalapati, Anuhya
    Mansfield, Aaron S.
    CLINICAL CANCER RESEARCH, 2022, 28 (15) : 3179 - 3181
  • [20] RMC-6291, a next-generation tri-complex KRASG12C(ON) inhibitor, outperforms KRASG12C(OFF) inhibitors in preclinical models of KRASG12C cancers
    Nichols, Robert J.
    Yang, Y. C.
    Cregg, Jim
    Schulze, Chris J.
    Wang, Zhican
    Dua, Richa
    Jiang, Jingjing
    Garrenton, Lindsay S.
    Nasholm, Nicole
    Bermingham, Alun
    Knox, John E.
    Seamon, Kyle
    Longhi, Michael
    Chou, Kang-Jye
    Li, Shaoling
    Wildes, David P.
    Singh, Mallika
    Koltun, Elena S.
    Gill, Adrian L.
    Smith, Jacqueline A. M.
    CANCER RESEARCH, 2022, 82 (12)