Metal organic framework modulated nanozymes tailored with their biomedical approaches

Nanozymes are the paradigm for bridging inorganic nanomaterials with biology and environment for taking the spontaneous responsibilities to outplay natural enzymes. Metal-organic frameworks (MOFs) are mesoporous materials of inorganic-organic coordination, bearing ampoules of active/target sites and having the tendency to mimic natural enzymes. Thus MOF-based nanozymes (NZs) could be recognized for their tremendous potential for bio-catalysis. However, MOFs are of four types namely: modified MOFs, pristine MOFs, MOF-derived materials and MOFs comprised of natural enzymes. The MOFs-based NZ modulated via ultrasound, light, and heat revealed diversified applications. This article is concentrated on different methods for the preparation of MOF-based NZ for mimicking the responses of catalases, multifunctional enzymes, oxidases, superoxide dismutase, hydrolases, and peroxidases, progress and challenges of MOFs/MOF-based materials for exploiting their recent and futuristic approaches in biomedical sector. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.