Development of a prognostic nomogram for esophageal squamous cell carcinoma patients received radiotherapy based on clinical risk factors

被引:0
|
作者
Li, Yang [1 ]
Shao, Xian [2 ]
Dai, Li-Juan [1 ]
Yu, Meng [3 ]
Cong, Meng-Di [4 ]
Sun, Jun-Yi [5 ]
Pan, Shuo [6 ]
Shi, Gao-Feng [1 ]
Zhang, An-Du [6 ]
Liu, Hui [1 ]
机构
[1] Hebei Med Univ, Hosp 4, Dept Computed Tomog & Magnet Resonance Imaging, Shijiazhuang, Hebei, Peoples R China
[2] Fourth Hosp Shijiazhuang, Dept Anesthesiol, Shijiazhuang, Hebei, Peoples R China
[3] Hebei Med Univ, Hosp 2, Shijiazhuang, Hebei, Peoples R China
[4] Hebei Childrens Hosp, Dept Computed Tomog & Magnet Resonance Imaging, Shijiazhuang, Hebei, Peoples R China
[5] First Hosp Qinhuangdao, Dept Radiol, Qinhuangdao, Hebei, Peoples R China
[6] Hebei Med Univ, Hosp 4, Dept Radiotherapy, Shijiazhuang, Hebei, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
carcinoma; squamous cell; esophageal neoplasms; radiotherapy; locoregional recurrence-free survival; nomogram; 8TH EDITION; ESOPHAGOGASTRIC JUNCTION; CHEMORADIOTHERAPY; CANCER; CT;
D O I
10.3389/fonc.2024.1429790
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The goal of the study was to create a nomogram based on clinical risk factors to forecast the rate of locoregional recurrence-free survival (LRFS) in patients with esophageal squamous cell carcinoma (ESCC) who underwent radiotherapy (RT). Methods: In this study, 574 ESCC patients were selected as participants. Following radiotherapy, subjects were divided into training and validation groups at a 7:3 ratio. The nomogram was established in the training group using Cox regression. Performance validation was conducted in the validation group, assessing predictability through the C-index and AUC curve, calibration via the Hosmer-Lemeshow (H-L) test, and evaluating clinical applicability using decision curve analysis (DCA). Results: T stage, N stage, gross tumor volume (GTV) dose, location, maximal wall thickness (MWT) after RT, node size (NS) after RT, Delta computer tomography (CT) value, and chemotherapy were found to be independent risk factors that impacted LRFS by multivariate cox analysis, and the findings could be utilized to create a nomogram and forecast LRFS. the area under the receiver operating characteristic (AUC) curve and C-index show that for training and validation groups, the prediction result of LRFS using nomogram was more accurate than that of TNM. The LRFS in both groups was consistent with the nomogram according to the H-L test. The DCA curve demonstrated that the nomogram had a good prediction effect both in the groups for training and validation. The nomogram was used to assign ESCC patients to three risk levels: low, medium, or high. There were substantial variations in LRFS between risk categories in both the training and validation groups (p<0.001, p=0.003). Conclusions: For ESCC patients who received radiotherapy, the nomogram based on clinical risk factors could reliably predict the LRFS.
引用
收藏
页数:13
相关论文
共 50 条
  • [41] Identification of miRNAs as prognostic factors for esophageal squamous cell carcinoma
    Chen, Meng
    Jin, Dacheng
    Wang, Bing
    Gou, Yunjiu
    Dong, Xinchun
    MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2020, 17 (03) : 2302 - 2309
  • [42] Prognostic nomogram and risk factors for predicting survival in patients with pT2N0M0 esophageal squamous carcinoma
    Kang, Mei
    Wang, Yichun
    Yang, Mingwei
    Wang, Xiumei
    Zhu, Liyang
    Zhang, Mei
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [43] Prognostic nomogram and risk factors for predicting survival in patients with pT2N0M0 esophageal squamous carcinoma
    Mei Kang
    Yichun Wang
    Mingwei Yang
    Xiumei Wang
    Liyang Zhu
    Mei Zhang
    Scientific Reports, 13
  • [44] Radiotherapy for elderly patients with esophageal squamous cell carcinoma: a SEER based analysis
    Zhang, J.
    Li, M.
    Gong, H.
    Huang, W.
    Li, B.
    RADIOTHERAPY AND ONCOLOGY, 2018, 127 : S792 - S792
  • [45] Postoperative radiotherapy in squamous cell carcinoma of the larynx - Prognostic factors
    Przeorek, W
    Skladowski, K
    Przeorek, C
    Maciejewski, B
    EUROPEAN JOURNAL OF CANCER, 1997, 33 : 855 - 855
  • [46] Prognostic nomogram for patients with tongue squamous cell carcinoma: A SEER-based study
    Gu, Yifan
    Qian, Cheng
    Yu, Lu
    Fang, Hongzhe
    Wang, Jintao
    Wu, Peipei
    Zhong, Liangjun
    Liu, Kai
    He, Rui
    ORAL DISEASES, 2024, 30 (02) : 292 - 306
  • [47] Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma
    Baba, Yoshifumi
    Harada, Kazuto
    Ida, Satoshi
    Kurashige, Junji
    Hiyoshi, Yukiharu
    Iwagami, Shiro
    Miyamoto, Yuji
    Sakamoto, Yasuo
    Yoshida, Naoya
    Watanabe, Masayuki
    Baba, Hideo
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [48] Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma
    Harada, K.
    Ida, S.
    Baba, Y.
    Ishimoto, T.
    Kosumi, K.
    Tokunaga, R.
    Izumi, D.
    Ohuchi, M.
    Nakamura, K.
    Kiyozumi, Y.
    Imamura, Y.
    Iwatsuki, M.
    Iwagami, S.
    Miyamoto, Y.
    Sakamoto, Y.
    Yoshida, N.
    Watanabe, M.
    Baba, H.
    DISEASES OF THE ESOPHAGUS, 2016, 29 (06) : 627 - 633
  • [49] Prognostic factors for salvage endoscopic resection for esophageal squamous cell carcinoma after chemoradiotherapy or radiotherapy alone
    Kondo, Shinya
    Tajika, Masahiro
    Tanaka, Tsutomu
    Kodaira, Takeshi
    Mizuno, Nobumasa
    Hara, Kazuo
    Hijioka, Susumu
    Imaoka, Hiroshi
    Goto, Hidemi
    Yamao, Kenji
    Niwa, Yasumasa
    ENDOSCOPY INTERNATIONAL OPEN, 2016, 4 (08) : E841 - E848
  • [50] Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma
    Su, Xiao-Dong
    Zhang, Dong-Kun
    Zhang, Xu
    Lin, Peng
    Long, Hao
    Rong, Tie-Hua
    JOURNAL OF THORACIC DISEASE, 2014, 6 (07) : 949 - 957