Anti-inflammatory mechanism of Apolipoprotein A-I

被引:4
|
作者
Tao, Xia [1 ]
Tao, Ran [1 ]
Wang, Kaiyang [1 ]
Wu, Lidong [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Emergency, Nanchang, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
Apolipoprotein A-I; macrophage; dendritic cell; neutrophil; T lymphocyte; anti-inflammatory; HIGH-DENSITY-LIPOPROTEIN; SYNTHETIC PEPTIDE ANALOGS; ACUTE LUNG INJURY; APOA-I; HUMAN MONOCYTES; MYOCARDIAL-INFARCTION; AMPHIPATHIC HELIX; INFLAMMATION; CHOLESTEROL; CELL;
D O I
10.3389/fimmu.2024.1417270
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Apolipoprotein A-I(ApoA-I) is a member of blood apolipoproteins, it is the main component of High density lipoprotein(HDL). ApoA-I undergoes a series of complex processes from its generation to its composition as spherical HDL. It not only has a cholesterol reversal transport function, but also has a function in modulating the inflammatory response. ApoA-I exerts its anti-inflammatory effects mainly by regulating the functions of immune cells, such as monocytes/macrophages, dendritic cells, neutrophils, and T lymphocytes. It also modulates the function of vascular endothelial cells and adipocytes. Additionally, ApoA-I directly exerts anti-inflammatory effects against pathogenic microorganisms or their products. Intensive research on ApoA-I will hopefully lead to better diagnosis and treatment of inflammatory diseases.
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页数:9
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