Supramolecular hydrogel of mycophenolic acid for treating allergic conjunctivitis

被引：0

作者：

Pu, Guojuan ^{[1
]}

Liang, Zhen ^{[1
]}

Shi, Jieran ^{[1
]}

Lu, Ping ^{[1
]}

Xia, Huiyun ^{[1
]}

Tao, Yuan ^{[1
]}

Qing, Huiling ^{[1
]}

Zhang, Junjie ^{[1
]}

机构：

[1] Peoples Hosp Zhengzhou Univ, Henan Eye Hosp, Henan Prov Peoples Hosp, Zhengzhou 450003, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024年 / 101卷

关键词：

Peptide; Self-assembled; Hydrogel; Mycophenolic acid; Allergic conjunctivitis; MANAGEMENT; THERAPY;

D O I：

10.1016/j.jddst.2024.106152

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mycophenolic acid (MPA) is an immunosuppressant less commonly utilized in allergic conjunctivitis. Peptidebased hydrogels improve material performance and are used in different biomedical applications. The current study reported that a cationic peptide Nap-FFKK and MPA were co-assembled into K-M hydrogel for sustained MPA delivery. The study evaluated cytotoxicity in vitro and its effectiveness in alleviating allergic conjunctivitis symptoms with a model. The current study demonstrates a promising strategy for using peptides as vehicles for sustained MPA delivery to the eye for ophthalmic applications.

引用

页数：6

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