Supramolecular hydrogel of mycophenolic acid for treating allergic conjunctivitis

Mycophenolic acid (MPA) is an immunosuppressant less commonly utilized in allergic conjunctivitis. Peptidebased hydrogels improve material performance and are used in different biomedical applications. The current study reported that a cationic peptide Nap-FFKK and MPA were co-assembled into K-M hydrogel for sustained MPA delivery. The study evaluated cytotoxicity in vitro and its effectiveness in alleviating allergic conjunctivitis symptoms with a model. The current study demonstrates a promising strategy for using peptides as vehicles for sustained MPA delivery to the eye for ophthalmic applications.