Neoadjuvant Capecitabine Plus Temozolomide in Atypical Lung NETs

被引:0
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作者
Evangelou, Georgios [1 ]
Vamvakaris, Ioannis [2 ]
Konstantopoulou, Irene [3 ]
Syrigos, Konstantinos [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Dept Med 3, Athens, Greece
[2] Sotiria Gen Hosp Chest Dis Athens, Pathol, Athens, Greece
[3] Natl Ctr Sci Res Demokritos, Canc Genet, Athens, Greece
来源
ONCOLOGY-NEW YORK | 2024年 / 38卷 / 07期
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Neoadjuvant and adjuvant treatment in lung neuroendocrine tumors (NETs) is a field that has not been explored in-depth, with little information on the impact on disease-free survival. This case study highlights the effectiveness of neoadjuvant treatment with capecitabine plus temozolomide (CAPTEM) in a woman with well-differentiated atypical carcinoid. The patient was asymptomatic at diagnosis and was referred to the outpatient NET clinic at Sotiria Hospital in Athens, following an incidental finding on a chest x-ray. F-18-fluorodeoxyglucose (FDG) PET/CT and Ga-68-Dotatoc PET/CT revealed another mass in the pancreas, with avidity in both imaging studies. The patient underwent treatment for 6 months with CAPTEM with a response in the lung NET and mediastinal lymph nodes. However, the mass in the pancreas slightly increased and was removed with a central pancreatectomy. The patient continued treatment with CAPTEM for 6 more months. There was further response according to RECIST 1.1 criteria (partial response in the mediastinal lymph nodes and a 21% regression in the primary tumor size). Pathology report after lobectomy with lymph node dissection showed a pathologic complete response in the mediastinal lymph nodes. Twenty-four months after surgery, the patient remains disease-free and has a good quality of life. Although large clinical trials are needed, this case study underlines the value of preoperative chemotherapy in atypical carcinoids.
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