Coaching LSD1 to ignore acetylation

被引:0
|
作者
Black, Joshua C. [1 ]
Kutateladze, Tatiana G. [1 ]
机构
[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA
关键词
D O I
10.1038/s41589-024-01710-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Engineered demethylase LSD1 opens a new avenue in developing tools to study intricate relationships between histone post-translational modifications that can be enzymatically edited.
引用
收藏
页码:162 / 163
页数:2
相关论文
共 50 条
  • [1] A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors
    Dong, Jianshu
    Pervaiz, Waqar
    Tayyab, Bilal
    Li, Die
    Kang, Lei
    Zhang, Huimin
    Gong, Huimin
    Ma, Xinli
    Li, Jian
    Agboyibor, Clement
    Bi, Yuefeng
    Liu, Hongmin
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 240
  • [2] Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1
    Dai, Xing-Jie
    Liu, Ying
    Xue, Lei-Peng
    Xiong, Xiao-Peng
    Zhou, Ying
    Zheng, Yi-Chao
    Liu, Hong-Min
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (05) : 2466 - 2488
  • [3] Taking LSD1 to a new high
    Wysocka, J
    Milne, TA
    Allis, CD
    CELL, 2005, 122 (05) : 654 - 658
  • [4] LSD1 tunes adipose tissues
    Andrea Du Toit
    Nature Reviews Molecular Cell Biology, 2014, 15 (7) : 430 - 430
  • [5] Inhibition of LSD1 for the treatment of cancer
    Smitheman, Kimberly
    Cusan, Monica
    Liu, Yan
    Butticello, Michael
    Pappalardi, Melissa
    Foley, James
    Federowicz, Kelly
    Van Aller, Glenn
    Kasparec, Jiri
    Tian, Xinrong
    Suarez, Dominic
    Schneck, Jess
    Carson, Jeff
    McDevitt, Patrick
    Ho, Thau
    McHugh, Charles
    Miller, William
    Armstrong, Scott
    Hann, Christine
    Johnson, Neil
    Kruger, Ryan G.
    Mohammad, Helai P.
    Kamat, Shekhar
    CANCER RESEARCH, 2015, 75
  • [6] LSD1 modulation by allosteric ligands
    Emond, Wei B.
    Geitmann, Matthis
    Jarvius, Malin
    Koehler, Konrad
    Kallblad, Per
    Niklasson, Mia
    Parrow, Vendela
    Sawant, Rajiv
    Sjoberg, Maria
    Winquist, Johan
    Segerman, Anna
    Bremberg, Ulf
    CANCER RESEARCH, 2019, 79 (13)
  • [7] Potentiation of immunotherapy by LSD1 modulation
    Emond, Wei B.
    Sawant, Rajiv
    Geitmann, Matthis
    Winquist, Johan
    Brandt, Peter
    Bremberg, Ulf
    Kallblad, Per
    Parrow, Vendela
    Andersson, Claes
    Blom, Kristin
    Najafi, Nasrin
    Bergstrom, Tobias
    Swartling, Fredrik J.
    Hellstrom, Mats
    Koehler, Konrad F.
    CANCER RESEARCH, 2023, 83 (07)
  • [8] Discovery of reversible LSD1 inhibitors
    Kanouni, Toufike
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [9] LSD1 Makes Fat Colorful
    Straub, Leon G.
    Wolfrum, Christian
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2017, 28 (01): : 1 - 2
  • [10] The lasting influence of LSD1 in the blood
    Dent, Sharon Y. R.
    Chandra, Joya
    ELIFE, 2013, 2